Methods of treatment of Alzheimer's disease
AssigneeNeuralab Limited
InventorDale B. Schenk
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Abstract
Disclosed are pharmaceutical compositions and methods for preventing or treating a number of amyloid diseases, including Alzheimer's disesase, prion diseases, familial amyloid neuropathies and the like. The pharmaceutical compositions include immunologically reactive amounts of amyloid fibril components, particularly fibril-forming peptides or proteins. Also disclosed are therapeutic compositions and methods which use immune reagents that react with such fibril components.
Claims58
A method of treating Alzheimer's disease in a mammalian subject, comprising administering to the subject a dosage of;
- (a) an immunogenic Aβ fragment effective to produce an immune response comprising antibodies against Aβ;
- and, (b) an adjuvant that augments the immune response to Aβ, thereby treating Alzheimer's disease.
A method of prophylaxis of Alzheimer's disease in a mammalian subject, comprising administering to the subject a dosage of:
- (a) an immunogenic Aβ fragment effective to produce an immune response comprising antibodies against Aβ and, (b) an adjuvant that augments the immune response to the Aβ, thereby effecting prophylaxis of Alzheimer's disease.
Dependencies are inferred from the claim text.