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US 6,869,975 B2Granted
Linked biaryl compounds
AssigneesTularik Inc., Japan Tobacco Inc.
InventorsHiroyuki Abe, Jonathan Houze, Hisashi Kawasaki, Frank Kayser, Rajiv Sharma, Samuel Sperry
Life of this patent
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Abstract
Compounds, compositions and methods that are useful for the treatment of metabolic disorders, inflammatory diseases and cancer are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in lipid metabolism, inflammation and cell proliferation. The subject compounds are linked biaryl compounds.
Claims28
A compound having the formula (Ia):
- R1O2C—CRaRb—Y—Ar1—X—Ar2—Z1—Z2—Ar3 Ia
- or a pharmaceutically acceptable salt or prodrug thereof, wherein
- X is selected from the group consisting of S(O)m, CR′R″ and SO2NR″;
- Y is O or CR′R″;
- Z1 and Z2 are independently selected from the group consisting of O, S(O)m, (CR′R″)n, N(R″), C(O)NR″ and CR′R″C(O)NR′″;
- alternatively, Z1 and Z2 may be combined to form (C2-C4)alkenyl;
- Ar1 and Ar2 are independently an aromatic group;
- Ar3 is aryl;
- R1 is selected from the group consisting of hydrogen, (C1-C8)alkyl and aryl(C1-C4)alkyl;
- Ra and Rb are independently selected from the group consisting of hydrogen, (C1-C4)alkyl, aryl and aryl(C1-C4)alkyl;
- each R′, R″ and R′″ is independently selected from the group consisting of hydrogen, (C1-C4)alkyl, aryl and aryl(C1-C4)alkyl;
- the subscript m is an integer from 0 to 2;
- and
- the subscript n is an integer from 1 to 2.
11 more elements
A compound having the formula_(Ia):
- R1O2C—CRaRb—Y—Ar1—X—Ar2—Z1—Z2—Ar3 Ia
- or a pharmaceutically acceptable salt or prodrug thereof, wherein
- X is S;
- Y is O;
- Z1 is (CR′R″)n;
- Z2 is O;
- Ar1 and Ar2 are independently phenyl;
- Ar3 is phenyl;
- and
- R1 is selected from the group consisting of hydrogen, (C1-C8)alkyl and aryl(C1-C4)alkyl;
- Ra and Rb are independently selected from the group consisting of hydrogen, (C1-C4)alkyl, aryl and aryl(C1-C4)alkyl;
- each R′ and R″ and is independently selected from the group, consisting of hydrogen, (C1-C4)alkyl, aryl and aryl(C1-C4)alkyl;
- and
- the subscript n is an integer from 1 to 2.
11 more elements
Dependencies are inferred from the claim text.