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US 6,849,403 B1Granted
Apparatus and method for drug screening
AssigneeExact Sciences Corporation
InventorAnthony P. Shuber
Life of this patent
Estimating the term…
Abstract
The present invention provides kits and methods for screening drugs and drug candidates for activity by determining the presence or absence of high integrity nucleic acid in a sample.
Claims26
A method for screening drug activity, the method comprising the steps of:
- (a) determining a baseline level of high integrity nucleic acid associated with a nucleic acid locus in a first sample obtained from a patient having a disease or at least one indicium of a disease, wherein the high integrity nucleic acid is derived from a genome of the patient and the disease comprises at least one of cancer, pre-cancer, a disease associated with apoptosis, and a disease associated with programmed cell death;
- (b) treating the patient with a drug candidate;
- and
- (c) determining whether the high integrity nucleic acid associated with the nucleic acid locus in a second sample obtained from the patient is reduced.
1 more element
A method for screening drug activity, the method comprising the steps of:
- (a) determining a baseline level of high integrity nucleic acid associated with a nucleic acid locus in a sample from a subject having a disease or at least one indicium of a disease, wherein the high integrity nucleic acid is derived from a genome of the subject and the disease comprises at least one of cancer, pre-cancer, a disease associated with apoptosis, and a disease associated with programmed cell death;
- (b) treating the sample with a drug candidate;
- and
- (c) determining whether high integrity nucleic acid associated with the nucleic acid locus in the sample is reduced.
1 more element
A method for screening drug activity, the method comprising the steps of:
- (a) determining a baseline level of high integrity nucleic acid associated with a n nucleic acid locus in a sample from an animal model of a disease or an animal model that displays at least one indicium of a disease, wherein the high integrity nucleic acid is derived from a genome of the animal model and the disease comprises at least one of cancer, pre-cancer, a disease associated with apoptosis, and a disease associated with programmed cell death;
- (b) treating the animal model with a drug candidate;
- and
- (c) determining whether the high integrity nucleic acid associated with the nucleic acid locus in a second sample obtained from the animal model is reduced.
1 more element
Dependencies are inferred from the claim text.