Methods for tissue repair using adhesive materials
AssigneeCohesion Technologies, Inc.
InventorsLouis C. Sehl, Olof Mikael Trollsas, Donald G. Wallace, David Toman, Frank A. DeLustro, Jacqueline A. Schroeder, George H. Chu
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Abstract
A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.
Claims53
A method of repairing damaged tissue in a patient comprising the steps of:
- placing into contact with the damaged tissue an adhesive composition comprised of
- (i) a hydrophilic polymer;
- (ii) a crosslinkable component A having m nucleophilic groups, wherein m≧2;
- and
- (iii) a crosslinkable component B having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧2 and m+n>4;
- wherein each of components A and B is biocompatible and nonimmunogenic, and at least one of components A and B is hydrophilic polymer, and crosslinking of the composition results in a biocompatible, nonimmunogenic, crosslinked matrix.
The method of 28, wherein the synthetic hydrophilic polymer is a polyalkylene oxide selected from the group consisting of polyethylene glycol and poly(ethylene oxide)-poly(propylene oxide) copolymers.
Dependencies are inferred from the claim text.