US 6,805,868 B1Granted

Moraxella catarrhalis antigen, corresponding gene and uses thereof

AssigneeGlaxosmithkline Biologicals SA

InventorJoelle Thonnard

Life of this patent

Estimating the term…

Abstract

The invention provides BASB109 polypeptides and polynucleotides encoding BASB109 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

Claims13

Dependent claims

An isolated, recombinant polypeptide comprising a member selected from the group consisting of

(a) the amino acid sequence SEQ ID NO:2 and
(b) an immunogenic fragment of at least 15 contiguous amino acids of SEQ ID NO:2, wherein the immunogenic fragment, when administered to a subject in a suitable composition which can include an adjuvant, or a suitable carrier coupled to the polypeptide, induces an antibody or T-cell mediated immune response that recognizes the polypeptide SEQ ID NO:2;
wherein the immunogenic fragment is selected from one of the following contiguous segments of SEQ ID NO:2;
1-15;
2-16;
3-17;
4-18;
5-19;
6-20;
7-21;
8-22;
9-23;
10-24;
11-25;
12-26;
13-27;
14-28;
15-29;
16-30;
17-31;
18-32;
19-33;
20-34;
21-35;
22-36;
23-37;
24-38;
25-39;
26-40;
27-41;
28-42;
29-43;
30-44;
31-45;
32-46;
33-47;
34-48;
45-49;
46-50;
37-51;
38-52;
39-53;
40-54;
41-55;
42-56;
43-57;
44-58;
45-59;
46-60;
47-61;
48-62;
49-63;
50-64;
51-65;
52-66;
53-67;
54-68;
55-69;
56-70;
57-71;
58-72;
59-73;
60-74;
61-75;
62-76;
63-77;
64-78;
65-79;
66-80;
67-81;
68-82;
69-83;
70-84;
71-85;
72-86;
73-87;
74-88;
75-89;
76-90;
77-91;
78-92;
79-93;
80-94;
81-95;
82-96;
83-97;
84-98;
85-99;
86-100;
87-101;
88-102;
89-103;
90-104;
91-105;
92-106;
93-107;
94-108;
95-109;
96-110;
97-111;
98-112;
99-113;
100-114;
101-115;
102-116;
103-117;
104-118;
105-119;
106-120;
107-121;
108-122;
109-123;
110-124;
111-125;
112-126;
113-127;
114-128;
115-129;
116-130;
117-131;
118-132;
119-133;
120-134;
121-135;
122-136;
123-137;
124-138;
125-139;
126-140;
127-141;
128-142;
129-143;
130-144;
131-145;
132-146;
133-147;
134-148;
135-149;
136-150;
137-151;
138-152;
139-153;
140-154;
141-155;
142-156;
143-157;
144-158;
145-159;
146-160;
147-161;
148-162;
149-163;
150-164;
151-165;
152-166;
153-167;
154-168;
155-169;
156-170;
157-171;
158-172;
159-173;
160-174;
161-175;
162-176;
163-177;
164-178;
165-179;
166-180;
167-181;
168-182;
169-183;
170-184;
171-185;
172-186;
173-187;
174-188;
175-189;
176-190;
177-191;
198-212;
199-213;
200-214;
201-215;
202-216;
203-217;
204-218;
205-219;
206-220;
207-221;
208-222;
209-223;
210-224;
211-225;
212-226;
213-227;
214-228;
215-229;
216-230;
217-231;
218-232;
219-233;
220-234;
221-235;
222-236;
223-237;
224-238;
225-239;
226-240;
227-241;
228-242;
229-243;
230-244;
231-245;
232-246;
233-247;
234-248;
235-249;
236-240;
237-241;
238-252;
239-253;
240-254;
241-255;
242-256;
243-257;
244-258;
245-259;
246-260;
247-261;
248-262;
249-263;
250-264;
251-265;
252-266;
253-267;
254-268;
255-269;
256-270;
257-271;
258-272;
259-273;
260-274;
261-275;
262-276;
263-277;
264-278;
265-279;
266-280;
267-281;
268-282;
269-283;
270-284;
271-285;
272-286;
273-287;
274-288;
275-289;
276-290;
277-291;
278-292;
279-293;
280-294;
281-295;
282-296;
283-297;
284-298;
285-299;
286-300;
287-301;
288-302;
289-303;
290-304;
291-305;
292-306;
293-307;
294-308;
295-309;
296-310;
297-311;
298-312;
299-313;
300-314;
301-315;
302-316;
303-317;
304-318;
305-319;
306-320;
307-321;
308-322;
309-323;
310-324;
311-325;
312-326;
313-327;
314-328;
315-329;
316-330;
317-331;
318-332;
319-333;
320-334;
321-335;
322-336;
323-337;
324-338;
325-339;
326-340;
327-341;
328-342;
329-343;
330-344;
331-345;
332-346;
333-347;
334-348;
335-349;
336-350;
337-351;
338-352;
339-353;
340-354;
341-355;
342-356;
343-357;
344-358;
345-359;
346-360;
347-361;
348-362;
349-363;
350-364;
351-365;
352-366;
353-367;
354-368;
355-369;
356-370;
357-371;
358-372;
359-373;
360-374;
361-375;
362-376;
363-377;
364-378;
365-379;
366-380;
367-381;
368-382;
369-383;
370-384;
371-385;
372-386;
373-387;
374-388;
375-389;
376-390;
377-391;
378-392;
379-393;
380-394;
381-395;
382-396;
383-397;
384-398;
385-399;
386-400;
387-401;
388-402;
389-403;
390-404;
391-405;
392-406;
393-407;
394-408;
395-409;
396-410;
397-411;
398-412;
399-413;
400-414;
401-415;
402-416;
403-417;
404-418;
405-419;
406-420;
407-421;
408-422;
409-423;
410-424;
411-425;
412-426;
413-427;
414-428;
415-429;
416-430;
417-431;
418-432;
419-433;
420-434;
421-435;
422-436;
423-437;
424-438;
425-439;
426-440;
427-441;
428-442;
429-443;
430-444;
431-445;
432-446;
433-447;
434-448;
435-449;
436-450;
437-451;
438-452;
439-453;
440-454;
441-455;
442-456;
443-457;
444-458;
445-459;
446-460;
447-461;
448-462;
449-463;
450-464;
451-465;
452-466;
453-467;
454-468;
455-469;
456-470;
457-471;
458-472;
459-473;
460-474;
461-475;
462-476;
463-477;
464-478;
465-479;
466-480;
467-481;
468-482;
469-483;
470-484;
471-485;
472-486;
473-487;
474-488;
475-489;
476-490;
477-491;
478-492;
479-493;
480-494;
481-495;
482-496;
483-497;
484-498;
485-499;
486-500;
487-501;
and 488-502.

468 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/088,045Filed 7 Jun 2002
Priority: EP 992169114 Sep 1999
Granted: 19 Oct 2004
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07K 14/212
From Pseudomonadaceae: moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
C07K 16/1214
Gram-negative bacteria: pseudomonadaceae
A61K 39/00
Medicinal preparations containing antigens or antibodies
A61K 2039/505
Medicinal preparations containing antigens or antibodies: comprising antibodies

Family

No related US applications are recorded in the indexed filing history.

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Citations

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Abstract

An isolated, recombinant polypeptide comprising a member selected from the group consisting of

(a) the amino acid sequence SEQ ID NO:2 and
(b) an immunogenic fragment of at least 15 contiguous amino acids of SEQ ID NO:2, wherein the immunogenic fragment, when administered to a subject in a suitable composition which can include an adjuvant, or a suitable carrier coupled to the polypeptide, induces an antibody or T-cell mediated immune response that recognizes the polypeptide SEQ ID NO:2;
wherein the immunogenic fragment is selected from one of the following contiguous segments of SEQ ID NO:2;
1-15;
2-16;
3-17;
4-18;
5-19;
6-20;
7-21;
8-22;
9-23;
10-24;
11-25;
12-26;
13-27;
14-28;
15-29;
16-30;
17-31;
18-32;
19-33;
20-34;
21-35;
22-36;
23-37;
24-38;
25-39;
26-40;
27-41;
28-42;
29-43;
30-44;
31-45;
32-46;
33-47;
34-48;
45-49;
46-50;
37-51;
38-52;
39-53;
40-54;
41-55;
42-56;
43-57;
44-58;
45-59;
46-60;
47-61;
48-62;
49-63;
50-64;
51-65;
52-66;
53-67;
54-68;
55-69;
56-70;
57-71;
58-72;
59-73;
60-74;
61-75;
62-76;
63-77;
64-78;
65-79;
66-80;
67-81;
68-82;
69-83;
70-84;
71-85;
72-86;
73-87;
74-88;
75-89;
76-90;
77-91;
78-92;
79-93;
80-94;
81-95;
82-96;
83-97;
84-98;
85-99;
86-100;
87-101;
88-102;
89-103;
90-104;
91-105;
92-106;
93-107;
94-108;
95-109;
96-110;
97-111;
98-112;
99-113;
100-114;
101-115;
102-116;
103-117;
104-118;
105-119;
106-120;
107-121;
108-122;
109-123;
110-124;
111-125;
112-126;
113-127;
114-128;
115-129;
116-130;
117-131;
118-132;
119-133;
120-134;
121-135;
122-136;
123-137;
124-138;
125-139;
126-140;
127-141;
128-142;
129-143;
130-144;
131-145;
132-146;
133-147;
134-148;
135-149;
136-150;
137-151;
138-152;
139-153;
140-154;
141-155;
142-156;
143-157;
144-158;
145-159;
146-160;
147-161;
148-162;
149-163;
150-164;
151-165;
152-166;
153-167;
154-168;
155-169;
156-170;
157-171;
158-172;
159-173;
160-174;
161-175;
162-176;
163-177;
164-178;
165-179;
166-180;
167-181;
168-182;
169-183;
170-184;
171-185;
172-186;
173-187;
174-188;
175-189;
176-190;
177-191;
198-212;
199-213;
200-214;
201-215;
202-216;
203-217;
204-218;
205-219;
206-220;
207-221;
208-222;
209-223;
210-224;
211-225;
212-226;
213-227;
214-228;
215-229;
216-230;
217-231;
218-232;
219-233;
220-234;
221-235;
222-236;
223-237;
224-238;
225-239;
226-240;
227-241;
228-242;
229-243;
230-244;
231-245;
232-246;
233-247;
234-248;
235-249;
236-240;
237-241;
238-252;
239-253;
240-254;
241-255;
242-256;
243-257;
244-258;
245-259;
246-260;
247-261;
248-262;
249-263;
250-264;
251-265;
252-266;
253-267;
254-268;
255-269;
256-270;
257-271;
258-272;
259-273;
260-274;
261-275;
262-276;
263-277;
264-278;
265-279;
266-280;
267-281;
268-282;
269-283;
270-284;
271-285;
272-286;
273-287;
274-288;
275-289;
276-290;
277-291;
278-292;
279-293;
280-294;
281-295;
282-296;
283-297;
284-298;
285-299;
286-300;
287-301;
288-302;
289-303;
290-304;
291-305;
292-306;
293-307;
294-308;
295-309;
296-310;
297-311;
298-312;
299-313;
300-314;
301-315;
302-316;
303-317;
304-318;
305-319;
306-320;
307-321;
308-322;
309-323;
310-324;
311-325;
312-326;
313-327;
314-328;
315-329;
316-330;
317-331;
318-332;
319-333;
320-334;
321-335;
322-336;
323-337;
324-338;
325-339;
326-340;
327-341;
328-342;
329-343;
330-344;
331-345;
332-346;
333-347;
334-348;
335-349;
336-350;
337-351;
338-352;
339-353;
340-354;
341-355;
342-356;
343-357;
344-358;
345-359;
346-360;
347-361;
348-362;
349-363;
350-364;
351-365;
352-366;
353-367;
354-368;
355-369;
356-370;
357-371;
358-372;
359-373;
360-374;
361-375;
362-376;
363-377;
364-378;
365-379;
366-380;
367-381;
368-382;
369-383;
370-384;
371-385;
372-386;
373-387;
374-388;
375-389;
376-390;
377-391;
378-392;
379-393;
380-394;
381-395;
382-396;
383-397;
384-398;
385-399;
386-400;
387-401;
388-402;
389-403;
390-404;
391-405;
392-406;
393-407;
394-408;
395-409;
396-410;
397-411;
398-412;
399-413;
400-414;
401-415;
402-416;
403-417;
404-418;
405-419;
406-420;
407-421;
408-422;
409-423;
410-424;
411-425;
412-426;
413-427;
414-428;
415-429;
416-430;
417-431;
418-432;
419-433;
420-434;
421-435;
422-436;
423-437;
424-438;
425-439;
426-440;
427-441;
428-442;
429-443;
430-444;
431-445;
432-446;
433-447;
434-448;
435-449;
436-450;
437-451;
438-452;
439-453;
440-454;
441-455;
442-456;
443-457;
444-458;
445-459;
446-460;
447-461;
448-462;
449-463;
450-464;
451-465;
452-466;
453-467;
454-468;
455-469;
456-470;
457-471;
458-472;
459-473;
460-474;
461-475;
462-476;
463-477;
464-478;
465-479;
466-480;
467-481;
468-482;
469-483;
470-484;
471-485;
472-486;
473-487;
474-488;
475-489;
476-490;
477-491;
478-492;
479-493;
480-494;
481-495;
482-496;
483-497;
484-498;
485-499;
486-500;
487-501;
and 488-502.

468 more elements

Facts

Application

10/088,045Filed 7 Jun 2002

Priority

EP 992169114 Sep 1999

Granted

19 Oct 2004

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07K 14/212
From Pseudomonadaceae: moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
C07K 16/1214
Gram-negative bacteria: pseudomonadaceae
A61K 39/00
Medicinal preparations containing antigens or antibodies
A61K 2039/505
Medicinal preparations containing antigens or antibodies: comprising antibodies