Methods for the administration of adenovirus p53
AssigneeBoard of Regents, The University of Texas System
InventorsWei-Wei Zhang, Jack A. Roth
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Abstract
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected cells. Also disclosed are compositions and methods involving novel p53 adenovirus constructs, including methods for restoring p53 function and tumor suppression in cells and animals having abnormal p53.
Claims70
A method of treating a human cancer patient having a human malignancy, comprising administering regionally to said patient an amount of an adenovirus composition effective to prevent growth of malignant cells, wherein said adenovirus composition comprises an adenovirus vector construct comprising a p53 gene, dispersed in a pharmacologically acceptable solution.
A method of treating a human cancer patient comprising administering intravenously to said patient, in at least three administrations, an amount of an adenovirus composition effective to prevent growth of malignant cells, wherein said adenovirus composition comprises an adenovirus vector construct comprising a p53 gene, dispersed in a pharmacologically acceptable solution.
A method of treating a human cancer patient comprising instilling intratracheally to said patient, in at least three administrations, an amount of an adenovirus composition effective to effective to prevent growth of malignant cells, wherein said adenovirus composition comprises an adenovirus vector construct comprising a p53 gene, dispersed in a pharmacologically acceptable solution.
A method of treating a human cancer patient having a tumor, comprising administering by direct injection of the tumor, in at least three administrations, an amount of an adenovirus composition effective to inhibit growth of tumor cells, wherein said adenovirus composition comprises an adenovirus vector construct comprising a p53 gene, dispersed in a pharmacologically acceptable solution.
Dependencies are inferred from the claim text.