Two-phase, water-absorbent bioadhesive composition
AssigneesCorium International, Inc., A.V. Topchiev Institute of Petrochemical Synthsis, Russian Academy of Sciences
InventorsGary W. Cleary, Mikhail M. Feldstein, Valery G. Kulichikhin, Danir F. Bairamov
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Abstract
An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.
Claims21
A bioadhesive composition comprising a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase comprises a crosslinked hydrophobic polymer composition and the hydrophilic phase comprises a mixture of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionically bonding, or covalently bonded.
Dependencies are inferred from the claim text.