Enterococcus antigens and vaccines
AssigneeNabi
InventorsAli Ibrahim Fattom, Ramesh K. Sood, Sara E. Shepherd
Life of this patent
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Abstract
A majority of E. faecalis and E. faecium clinical isolates fall into two groups and three groups, respectively. Distinct antigens are associate with each of the five groups. The Enterococcus antigens are readily obtained from strains of E. faecalis and E. faecium, and can elicit production of protective antibodies. Accordingly, the antigens are useful for vaccines which protect against infection by clinically significant (pathogenic) Enterococcus isolates. The antigens and antibodies generated to the antigens are also useful in diagnostic assays.
Claims17
An isolated Enterococcus faecalis antigen comprising 2-acetamido-2-deoxy-glucose, rhamnose, glucose and 2-acetamido-2-deoxy-galactose wherein 2-acetamido-2-deoxy-glucose and rhamnose are in a 1:2 molar ratio.
An isolated Enterococcus antigen selected from the group consisting of an E. faecalis antigen comprising 2-acetamido-2-deoxy-glucose, rhamnose, glucose and 2-acetamido-2-deoxy-galactose, wherein 2-acetamido-2-deoxy-glucose and rhamnose are in a 1:2 molar ratio, an E. faecalis antigen comprising a trisaccharide repeat which comprises a 6-deoxy sugar, and an E. faecium antigen comprising 2-acetamido-2-deoxy-galactose and galactose.
Dependencies are inferred from the claim text.