US 6,723,725 B1 · Indole derivatives

Abstract

Indole derivatives of formula I, their salts and solvates, have valuable pharmacological properties together with good tolerability, as they have actions on the central nervous system: wherein R1 and R3 are as defined herein. The compounds have a strong affinity for 5-HT2A receptors, and furthermore exhibit 5HT2A receptor-antagonistic properties. These are therefore suitable both in veterinary and in human medicine for the treatment of functional disorders of the central nervous system and also of inflammation.

Claims38

Dependent claims

A compound of formula I

in which
R1 is Het1, or a phenyl radical which is unsubstituted or substituted by R2 and/or R4,
R2, R4,
R5, R6 in each case independently of one another are Hal, A, OA, OH, CN or acyl,
R3 is Het2 or a phenyl radical which is unsubstituted or substituted by R5 and/or R6,
Het1 is a mono- or binuclear unsaturated heterocyclic ring, which contains one, two or three identical or different heteroatoms, and is unsubstituted or mono- or disubstituted by Hal, A, OA or OH,
Het2 is an unsaturated heterocyclic ring which contains one or two identical or different heteroatoms, and is unsubstituted or mono- or disubstituted by Hal, A, or OA
A is alkyl having 1-6 C atoms, and
Hal is F, Cl, Br or I,
or a physiologically acceptable salt or solvate thereof.

7 more elements

Dependencies are inferred from the claim text.

Indole derivatives

Life of this patent

Indole derivatives

Life of this patent

Abstract

Claims38