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US 6,723,701 B2Granted
Protein analogs of brain-derived neurotrophic factor
AssigneeAmgen Inc.
InventorsThomas Charles Boone, Ellen Ngoi Yin Cheung, Susan Irene Hershenson, John David Young
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Abstract
The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3 and BDNF, can be increased by generating analogs that have a lower isoelectric point and, preferably, also a lower protein charge relative to the protein of native sequence.
Claims7
An isolated brain-derived neurotrophic factor (BDNF) polypeptide analog having an amino acid sequence selected from the group consisting of SEQ ID NO:
- 9 and SEQ ID NO:
- 10, wherein the isoelectric point is lower and the in vivo circulating life and/or absorption is increased for said analog relative to those properties of a wild-type BDNF polypeptide having an amino acid sequence of SEQ ID NO:8.
Dependencies are inferred from the claim text.