HMGI proteins in cancer and obesity
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsKiran K. Chada, Hena Ashar, Alex Tkachenko, Xianjin Zhou
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Abstract
The present invention relates to HMGI genes and proteins and methods of using the same. Embodiments of the invention pertain to methods for treating obesity, methods for treating a tumor, methods for producing a transgenic non-human mammal, methods for screening candidate compounds capable of inhibiting the biological activity of normal HMGI genes or proteins, and methods for detecting the presence of a tumor.
Claims1
A transgenic mouse whose genome comprises a homozygous disruption of the HMGI-C gene and a homozygous disruption of the leptin gene, where the disruptions cause smaller stature in the mouse as compared to an ob/ob mouse and increased weight as compared to a pygmy mouse.
Dependencies are inferred from the claim text.