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AssigneeBiora AB
InventorsRadim Cerny, Ivan Slaby, Lars Hammarström, Tilmann Wurtz, Cheng Dan Fong
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The invention relates to novel nucleic acid fragments encoding polypeptides which are capable of mediating contact between enamel and cell surface. The invention also relates to expression vectors containing the nucleic acid fragments according to the invention for production of the protein, organisms containing said expression vector, methods for producing the polypeptide, compositions comprising the polypeptides, antibodies or antibody fragments recognizing the polypeptides, and methods for treating various hard tissue diseases or disorders.
An at least partially purified nucleic acid encoding a polypeptide which comprises an amino acid subsequence S having a length of 20 amino acids, said subsequence S comprising at least one sequence element selected from the group consisting of the tetrapeptides DGEA (Asp-Gly-Glu-Ala), VTKG (Val-Thr-Lys-Gly), EKGE (Glu-Lys-Gly-Glu) and DKGE (Asp-Lys-Gly-Glu),
An at least partially purified nucleic acid, at least 18 nucleotides long, encoding a polypeptide, said nucleic acid being (I) a nucleic acid whose coding strand hybridizes with the noncoding strand of (a) a nucleic acid having the coding strand nucleotide sequence shown in SEQ ID NO:
An at least partially purified nucleic acid encoding a polypeptide which is at least six amino acids long, and which is bound by an antibody which also binds amelin-1, having the amino acid sequence of SEQ ID NO:2, or amelin-2, having the amino acid sequence of SEQ ID NO:4, said polypeptide mediating contact between enamel and cell surfaces.
An at least partially purified nucleic acid encoding a polypeptide comprises at least one sequence element selected from the group consisting of the tetrapeptides DGEA (Asp-Gly-Glu-Ala), VTKG (Val-Thr-Lys-Gly), EKGE (Glu-Lys-Gly-Glu) and DKGE (Asp-Lys-Gly-Glu),
Dependencies are inferred from the claim text.