Mutant herpes simplex viruses and uses thereof
AssigneeBiovex Limited
InventorsRobert S. Coffin, David S. Latchman, Nicholas J. Finnie
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Abstract
The present invention provides a herpes simplex virus strain having a functional ICP27 gene and lacking at lease a functional ICP4 gene and a functional ICP34.5 gene. It also provides the use of a herpes simplex virus strain which lacks at least a functional ICP4 gene and a functional ICP34.5 gene in the treatment of disorders of, or injuries to, the nervous system of a mammal.
Claims15
A herpes simplex virus having a functional ICP27 gene and which lacks functional ICP4 and functional ICP34.5 genes, a functional vhs gene and a functional VMW65 gene due to a mutation in said VMW65 gene which abolishes its transcriptional-activation activity.
Dependencies are inferred from the claim text.