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US 6,673,385 B1Granted
Methods for polymeric coatings stents
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsNi Ding, Deborra Sanders Millare, Syed F. A. Hossainy
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Abstract
This invention provides a method of forming a polymeric coating for a stent. The method can comprise applying a prepolymer or a combination of prepolymers to the stent and initiating polymerization to form a polymeric coating for the stent. The coating material can optionally contain a biologically active agent or combination of agents.
Claims18
A method of forming a polymeric coating for a stent, comprising:
- (a) applying a mixture of a monomer or a combination of monomers and an initiator of polymerization to the stent;
- and
- (b) initiating polymerization of the monomer or combination of monomers by subjecting the stent to thermal treatment or by exposing the stent to UV radiation, to form a polymeric coating for the stent, wherein:
- (i) the polymer forming the coating is selected from a group consisting of poly(glycol methacrylate), poly(methyl methacrylate), poly(ethyl methacrylate), poly(butyl methacrylate), poly(sulfanato ethyl methacrylate), poly(ethylene-co-vinyl acetate), poly(ethyl acrylate), poly(urethane-acrylate), poly(acrylamide-co-ethyl methacrylate), poly(divinyl benzene), poly(triethylene glycol-co-divinyl ether), poly(tri-methylol propane triacrylate), poly(pentaerythritol tetraacrylate), poly(Bisphenol A ethoxylate diacrylate), poly(allyl ether), poly(diallyl maleate), poly(vinylidene fluoride), poly(triallyl isocyanurate), and blends thereof, and
- (ii) the initiator is selected from a group consisting of benzophenone, 2,2-dimethoxy-2-phenylacetophenone, 1-hydroxycyclohexyl phenyl ketone, benzoin ethyl ether, phenyl azide, 2,2′-azobisisobutyronitrile, potassium persulfate, ammonium persulfate, and a blend of ammonium persulfate with sodium bisulfite.
2 more elements
A method of forming a polymeric coating on a stent, comprising:
- (a) spraying a radially expandable stent with a coating fluid, the fluid comprising a prepolymer and an therapeutic agent mixed with the prepolymer;
- and
- (b) causing the prepolymer to react to form a polymeric coating on the stent, wherein the active agent is contained in the polymeric coating, and wherein the polymer forming the coating is selected from a group consisting of poly(glycol methacrylate), poly(methyl methacrylate), poly(ethyl methacrylate), poly(butyl methacrylate), poly(sulfanato ethyl methacrylate), poly(ethylene-co-vinyl acetate), poly(ethyl acrylate), poly(urethane-acrylate), poly(acrylamide-co-ethyl methacrylate), poly(divinyl benzene), poly(triethylene glycol-co-divinyl ether), poly(tri-methylol propane triacrylate), poly(pentaerythritol tetraacrylate), poly(Bisphenol A ethoxylate diacrylate), poly(allyl ether), poly(diallyl maleate), poly(vinylidene fluoride), poly(triallyl isocyanurate), and blends thereof.
A method of forming a polymeric coating for a stent, comprising:
- (a) applying a mixture of an oligomer or a combination of oligomers and an initiator of polymerization to the stent;
- and
- (b) initiating polymerization of the oligomer or combination of oligomers by subjecting the stent to thermal treatment or by exposing the stent to UV radiation, to form a polymeric coating for the stent, wherein:
- (i) the polymer forming the coating is poly(urethane-acrylate);
- and
- (ii) the initiator is selected from a group consisting of benzophenone, 2,2-dimethoxy-2-phenylacetophenone, 1-hydroxycyclohexyl phenyl ketone, benzoin ethyl ether, phenyl azide, 2,2′-azobisisobutyronitrile, potassium persulfate, ammonium persulfate, and a blend of ammonium persulfate with sodium bisulfite.
3 more elements
A method of forming a polymeric coating for a stent, comprising:
- (a) applying a macromer or a combination of macromers to the stent;
- and
- (b) initiating polymerization of the macromer or combination of macromers to form a polymeric coating for the stent, wherein the polymer forming the coating is selected from a group consisting of poly(ethylene glycol diacrylate) and poly(caprolactone diacrylate).
Dependencies are inferred from the claim text.