Method and apparatus for electrospray mass spectrometric analysis
AssigneeJapan Science and Technology Corporation
InventorKentaro Yamaguchi
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Abstract
The invention is provides a method and an apparatus for performing electrospray ionization mass spectrometric analysis, which method can exactly analyze a mass of a molecular ion or a fragment ion of an unstable organometallic complex or a polymeric organic compound. The method includes cooling a sample to be analyzed which contains a solvent and is caused to flow out from a spray small-diameter tube with an inert gas for low temperature vaporization (A), and carrying out ionization and mass spectrometric analysis of the sample to be analyzed while cooling a chamber (7) for removing a solvent or an ion source shield (8) with liquid nitrogen.
Claims8
A method for performing electrospray mass spectrometric analysis, characterized by comprising atomizing a sample solution to be analyzed which contains a solvent and is caused to flow out from a small-diameter tube for spraying while the sample solution is cooled by means of a gas for vaporization;
- and ionizing the atomized sample solution to be analyzed while a chamber for removing a solvent and an ion source shield are cooled, to thereby perform mass spectrometric analysis of the sample.
An apparatus for performing electrospray mass spectrometric analysis, characterized by comprising
- (a) a small-diameter tube for spraying and for causing to flow out a sample solution to be analyzed containing a solvent;
- (b) a sheath tube which is co-axially provided with the tube for spraying and allows passage of a gas for cooling;
- (c) a chamber for removing a solvent and an ion source shield which are cooled;
- and
- (d) a mass spectrometer for ionizing by use of the solvent and performing mass analysis of a sample to be analyzed;
- (e) wherein an ion source formed through electrospraying is employed while the ion source is cooled by spraying liquid nitrogen directly to a chamber for removing a solvent and to an ion source shield.
Dependencies are inferred from the claim text.