Silyl and Heparin compositions
AssigneeInnerdyne, Inc.
InventorsRay Tsang, Shigemasa Osaki
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Abstract
The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: wherein R1 is an C1-18 alkyl or C6-32 aryl group, each R2 is independently selected from the group consisting of C1-18 alkyl and C6-32 aryl, R3 is N or O, n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding, with an adhesive molecule directly bound to the heparin molecule. In one embodiment, the coating comprises benzyl-(1,2 dimethyl)disilyl heparin, wherein an adhesive molecule, such as fibronectin, is bound to the heparin.
Claims15
A silyl and heparin covalent composition of Formula l:
- wherein
- R1 is a C1-8 alkyl or C6-32 aryl group,
- each R2 is independently selected from the group consisting of C1-8 alkyl and C6-32 aryl,
- R3 is N or O,
- n is a number from 1 to 10, and
- x is a number from 1 to 30.
Dependencies are inferred from the claim text.