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US 6,599,448 B1Granted
Radio-opaque polymeric compositions
AssigneeHydromer, Inc.
InventorsJoseph A. Ehrhard, Jr., Patrick Hennessey
Life of this patent
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Abstract
The present invention provides a radio-opaque composition including a polymer or monomer, wherein the polymer or monomer has a non-leachable radio-opaque moiety. The non-leachable radio-opaque moiety is covalently attached to the polymer or monomer.
Claims40
A radio-opaque composition comprising a polymer or monomer, and an antithrombotic, wherein said polymer or monomer has a non-leachable radio-opaque moiety, wherein said non-leachable radio-opaque moiety is covalently attached to said polymer or said monomer, and wherein said antithrombotic agent is releasable or non-releasable from said composition.
A radio-opaque primer comprising a monomer, wherein said monomer has a non-leachable radio-opaque moiety, wherein said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an ester, an aldehyde, an N-hydroxysuccinimide ester, an epoxide, a carboxylic ester, a tresylate, an anhydride, an alkyl halide, a carboxylic acid, a haloketone, an alkene, an alkyne or an acyl chloride;
- and wherein said monomer is covalently attached to an object by a covalent linkage.
A radio-opaque composition comprising:
- (a) a polymer or monomer, wherein said polymer or monomer has a non-leachable radio-opaque moiety, and
- (b) a polyvinylpyrrolidone-polyurethane complex, wherein said polymer is a natural polymer or a synthetic polymer or a combination thereof;
- wherein said synthetic polymer is a polymer blend, alloy, random copolymer, block copolymer, graft copolymer or homopolymer;
- wherein said synthetic polymer comprises poly(vinyl alcohol), poly(vinylpyrrolidone), poly(caprolactone), poly(hydroxybutarates), poly(caprolactams), poly(terephthalate), poly(vinyl chloride), poly(propylene), poly(ethylene oxide), poly(propylene oxide), poly(styrene), poly(ethylene), poly(urethanes), silicone elastomers or combinations thereof;
- wherein said monomer is an allyllic compound, amide, amine, anhydride, epoxide, isocyanate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said polymer or said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride or a carboxylic acid;
- and wherein said non-leachable radio-opaque moiety is covalently attached to said polymer or said monomer.
4 more elements
A radio-opaque primer comprising a monomer which is covalently attached to a non-leachable radio-opaque moiety, wherein said monomer is an allyllic compound, amide, amine, anhydride, epoxide, isocyanate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said monomer has at least one reactive functional group selected from the group consisting of an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride and a carboxylic acid;
- wherein said monomer adheres to an object.
A medical device covered with a composition comprising:
- (a) a polymer or a monomer wherein said polymer or said monomer has a non-leachable radio-opaque moiety, and
- (b) a polyvinylpyrrolidone-polyurethane complex, wherein said radio-opaque moiety is a halogenated aromatic compound with a reactive functional group;
- wherein said polymer is a natural polymer or a synthetic polymer or a combination thereof, wherein said synthetic polymer is a polymer blend, alloy, random copolymer, block copolymer, graft copolymer or homopolymer;
- wherein said synthetic polymer comprises poly(vinyl alcohol), poly(vinylpyrrolidone), poly(caprolactone), poly(hydroxybutarates), poly(caprolactams), poly(terephthalate), poly(vinyl chloride), poly(propylene), poly(ethylene oxide), poly(propylene oxide), poly(styrene), poly(ethylene), poly(urethanes), silicone elastomers or combinations thereof;
- wherein said monomer is an allyllic compound, amide, amine, anhydride, epoxide, isocyanate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said polymer or said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride, or a carboxylic acid.
3 more elements
A stent covered with a composition comprising:
- (a) a polymer or a monomer wherein said polymer or said monomer has a non-leachable radio-opaque moiety, and
- (b) a polyvinylpyrrolidone-polyurethane complex, wherein said radio-opaque moiety is a halogenated aromatic compound with a reactive functional group;
- wherein said polymer is a natural polymer or a synthetic polymer or a combination thereof;
- wherein said synthetic polymer is a polymer blend, alloy, random copolymer, block copolymer, graft copolymer or homopolymer;
- wherein said synthetic polymer comprises poly(vinyl alcohol), poly(vinylpyrrolidone), poly(caprolactone), poly(hydroxybutarates), poly(caprolactams), poly(terephthalate), poly(vinyl chloride), poly(propylene), poly(ethylene oxide), poly(propylene oxide), poly(styrene), poly(ethylene), poly(urethanes), silicone elastomers or combinations thereof;
- wherein said monomer is an allyllic compound, amide, amine, anhydride, epoxide, isocyanate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said polymer or said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride, or a carboxylic acid.
4 more elements
A method of rendering an object radio-opaque comprising:
- applying a composition to said object, wherein said composition comprises:
- (a) a polymer or monomer wherein said polymer or said monomer has a non-leachable radio-opaque moiety, and
- (b) a polyvinylpyrrolidone-polyurethane complex, wherein said polymer is a natural polymer or a synthetic polymer or a combination thereof, wherein said synthetic polymer is a polymer blend, alloy, random copolymer, block copolymer, graft copolymer or homopolymer, wherein said synthetic polymer comprises poly(vinyl alcohol), poly(vinylpyrrolidone), poly(caprolactone), poly(acrylamides), poly(hydroxybutarates), poly(caprolactams), poly(terephthalate), poly(vinyl chloride), poly(propylene), poly(ethylene oxide), poly(acrylic acid), poly(propylene oxide), poly(styrene), poly(ethylene), poly(urethanes), silicone elastomers or combinations thereof;
- wherein said monomer is an acrylate, allyllic compound, amide, amine, anhydride, epoxide, isocyanate, methacrylate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said polymer or said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride or a carboxylic acid.
2 more elements
A method of rendering an object radio-opaque comprising:
- applying a radio-opaque primer to said object, wherein said primer comprises a monomer, wherein said monomer has a non-leachable radio-opaque moiety, wherein said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an ester, an aldehyde, an N-hydroxysuccinimide ester, an epoxide, a carboxylic ester, a tresylate, an anhydride, an alkyl halide, a carboxylic acid, a haloketone, an alkene, an alkyne or an acyl chloride;
- and wherein said monomer is covalently attached to an object by a covalent linkage.
A method of rendering an object radio-opaque comprising:
- applying a primer to said object, wherein said primer comprises a monomer which is covalently attached to a non-leachable radio-opaque moiety, and a a polyvinylpyrrolidone-polyurethane complex;
- wherein said monomer is an allyllic compound, amide, amine, anhydride, epoxide, isocyanate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said monomer has at least one reactive functional group selected from the group consisting of an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride and a carboxylic acid;
- wherein said monomer adheres to an object.
1 more element
An object covered with a composition comprising:
- (a) a polymer or monomer, wherein said polymer or monomer has a non-leachable radio-opaque moiety, and
- (b) a polyvinylpyrrolidone-polyurethane complex, wherein said polymer is a natural polymer or a synthetic polymer or a combination thereof;
- wherein said synthetic polymer is a polymer blend, alloy, random copolymer, block copolymer, graft copolymer or homopolymer;
- wherein said synthetic polymer comprises poly(vinyl alcohol), poly(vinylpyrrolidone), poly(caprolactone), poly(hydroxybutarates), poly(caprolactams), poly(terephthalate), poly(vinyl chloride), poly(propylene), poly(ethylene oxide), poly(propylene oxide), poly(styrene), poly(ethylene), poly(urethanes), silicone elastomers or combinations thereof;
- wherein said monomer is an allyllic compound, amide, amine, anhydride, epoxide, isocyanate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said polymer or said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride or a carboxylic acid;
- and wherein said non-leachable radio-opaque moiety is covalently attached to said polymer or said monomer.
4 more elements
An object covered with a primer comprising:
- wherein said primer comprises a monomer, wherein said monomer has a non-leachable radio-opaque moiety, wherein said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an ester, an aldehyde, an N-hydroxysuccinimide ester, an epoxide, a carboxylic ester, a tresylate, an anhydride, an alkyl halide, a carboxylic acid, a haloketone, an alkene, an alkyne or an acyl chloride;
- and wherein said monomer is covalently attached to said object by a covalent linkage.
An object covered with a primer comprising:
- wherein said primer comprises a monomer and a polyvinylpyrrolidone-polyurethane complex;
- wherein said monomer has a non-leachable radio-opaque moiety, wherein said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an ester, an aldehyde, an N-hydroxysuccinimide ester, an epoxide, a carboxylic ester, a tresylate, an anhydride, an alkyl halide, a carboxylic acid, a haloketone, an alkene, an alkyne or an acyl chloride;
- and wherein said monomer adheres to said object.
A radio-opaque covering composition comprising:
- (a) a polymer or monomer, wherein said polymer or monomer has a non-leachable radio-opaque moiety, and
- (b) an aqueous coating solution comprising a blend of a polyacrylate and a poly(ethylene oxide), wherein said polymer is a natural polymer or a synthetic polymer or a combination thereof;
- wherein said synthetic polymer is a polymer blend, alloy, random copolymer, block copolymer, graft copolymer or homopolymer;
- wherein said synthetic polymer comprises poly(vinyl alcohol), poly(vinylpyrrolidone), poly(caprolactone), poly(hydroxybutarates), poly(caprolactams), poly(terephthalate), poly(vinyl chloride), poly(propylene), poly(ethylene oxide), poly(propylene oxide), poly(styrene), poly(ethylene), poly(urethanes), silicone elastomers or combinations thereof;
- wherein said monomer is an allyllic compound, amide, amine, anhydride, epoxide, isocyanate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said polymer or said monomer has at least one reactive functional group, wherein said reactive fuinctional group is an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride or a carboxylic acid;
- wherein said non-leachable radio-opaque moiety is covalently attached to said polymer or said monomer.
4 more elements
A radio-opaque covering composition comprising:
- a) a polymer or monomer, wherein said polymer or monomer has a non-leachable radio-opaque moiety, and
- (b) a block copolymer of a dimethylacrylamide and glycidyl methacrylate, wherein said polymer is a natural polymer or a synthetic polymer or a combination thereof;
- wherein said synthetic polymer is a polymer blend, alloy, random copolymer, block copolymer, graft copolymer or homopolymer;
- wherein said synthetic polymer comprises poly(vinyl alcohol), poly(vinylpyrrolidone), poly(caprolactone), poly(hydroxybutarates), poly(caprolactams), poly(terephthalate), poly(vinyl chloride), poly(propylene), poly(ethylene oxide), poly(propylene oxide), poly(styrene), poly(ethylene), poly(urethanes), silicone elastomers or combinations thereof;
- wherein said monomer is an allyllic compound, amide, amine, anhydride, epoxide, isocyanate, silyl, thiol compound, thioisocyanate, vinyl compound, ester, acid chloride, acrolein or acryloylchoride;
- and wherein said polymer or said monomer has at least one reactive functional group, wherein said reactive functional group is an isocyanate, an isothiocyanate, an epoxide, a carboxylic ester, a tresylate, an anhydride or a carboxylic acid;
- wherein said non-leachable radio-opaque moiety is covalently attached to said polymer or said monomer.
4 more elements
Dependencies are inferred from the claim text.