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US 6,590,079 B2Granted
Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same
AssigneeIxsys, Inc.
InventorsWilliam D. Huse, Scott M. Glaser
Life of this patent
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AssigneeIxsys, Inc.
InventorsWilliam D. Huse, Scott M. Glaser
Estimating the term…
The invention provides a Vitaxin antibody and a LM609 grafted antibody exhibiting selective binding affinity to αvβ3. The Vitaxin antibody consists of at least one Vitaxin heavy chain polypeptide and at least one Vitaxin light chain polypeptide or functional fragments thereof. Also provided are the Vitaxin heavy and light chain polypeptides and functional fragments. The LM609 grafted antibody consists of at least one CDR grafted heavy chain polypeptide and at least one CDR grafted light chain polypeptide or functional fragment thereof. Nucleic acids encoding Vitaxin and LM609 grafted heavy and light chains as well as nucleic acids encoding the parental non-human antibody LM609 are additionally provided. Functional fragments of such encoding nucleic acids are similarly provided.
An antibody comprising at least one heavy chain polypeptide comprising a variable region amino acid sequence as that shown in FIG. 1A (SEQ ID NO:2) and at least one light chain polypeptide comprising a variable region amino acid sequence as that shown in FIG. 1B (SEQ ID NO:4) or a functional fragment thereof, said antibody or functional fragment thereof having integrin αvβ3 binding activity, integrin αvβ3 binding specificity or integrin αvβ3-inhibitory activity.
A nucleic acid encoding a heavy chain polypeptide comprising the heavy chain variable region amino acid sequence of SEQ ID NO:2.
A nucleic acid encoding a functional fragment of a heavy chain variable region of an antibody having integrin αvβ3 binding activity, integrin αvβ3 binding specificity or integrin αvβ3-inhibitory activity, wherein the amino acid sequence of said heavy chain variable region consists of SEQ ID NO:2.
A nucleic acid encoding a CDR of the heavy chain polypeptide of SEQ ID NO:2.
A nucleic acid encoding a light chain polypeptide comprising the light chain variable region amino acid sequence of SEQ ID NO:4.
A nucleic acid encoding a functional fragment of a light chain variable region of an antibody having integrin αvβ3 binding activity, integrin αvβ3 binding specificity or integrin αvβ3-inhibitory activity, wherein the amino acid sequence of said light chain variable region consists of SEQ ID NO:4.
A nucleic acid encoding a CDR of the light chain polypeptide of SEQ ID NO:4.
A heavy chain polypeptide comprising a variable region amino acid sequence as that shown in FIG. 1A (SEQ ID NO:2) or functional fragment thereof.
A light chain polypeptide comprising a variable region amino acid sequence as that shown in FIG. 1B (SEQ ID NO:4) or a functional fragment thereof.
A LM609 CDR-grafted antibody comprising at least one LM609 CDR-grafted heavy chain polypeptide comprising a variable region amino acid sequence as that shown in FIG. 1A (SEQ ID NO:2) and at least one LM609 CDR-grafted light chain polypeptide comprising a variable region amino acid sequence as that shown in FIG. 7 (SEQ ID NO:32) or a functional fragment thereof, said LM609 CDR-grafted antibody or functional fragment thereof having integrin αvβ3 binding activity, integrin αvβ3 binding specificity or integrin αvβ3-inhibitory activity.
A nucleic acid encoding a LM609 CDR-grafted light chain polypeptide comprising the LM609 CDR-grafted light chain variable region amino acid sequence of SEQ ID NO:32.
A nucleic acid encoding a functional fragment of a light chain variable region of an antibody having integrin αvβ3 binding activity, integrin αvβ3 binding specificity or integrin αvβ3-inhibitory activity, wherein the amino acid sequence of said light chain variable region consists of SEQ ID NO:32.
A nucleic acid encoding a CDR of the LM609 CDR-grafted light chain polypeptide of SEQ ID NO:32.
A LM609 CDR-grafted light chain polypeptide comprising a variable region amino acid sequence as that shown in FIG. 7 (SEQ ID NO:32) or a functional fragment thereof.
A nucleic acid encoding a heavy chain polypeptide for monoclonal antibody LM609 comprising the heavy chain variable region amino acid sequence of SEQ ID NO:6.
A nucleic acid encoding a functional fragment of a heavy chain variable region of an antibody having integrin αvβ3 binding activity, integrin αvβ3 binding specificity or integrin αvβ3-inhibitory activity, wherein the amino acid sequence of said heavy chain variable region consists of SEQ ID NO:6.
A nucleic acid encoding a CDR of the heavy chain polypeptide of SEQ ID NO:6.
A nucleic acid encoding a light chain polypeptide for monoclonal antibody LM609 comprising the light chain variable region amino acid sequence of SEQ ID NO:8.
A nucleic acid encoding a functional fragment of a light chain variable region of an antibody having integrin αvβ3 binding activity, integrin αvβ3 binding specificity or integrin αvβ3-inhibitory activity, wherein the amino acid sequence of said light chain variable region consists of SEQ ID NO:8.
A nucleic acid encoding a CDR of the light chain polypeptide of SEQ ID NO:8.
Dependencies are inferred from the claim text.