Booster for therapy of disease with ultrasound and pharmaceutical IDLIQU composition containing the same
AssigneeEkos Corporation
InventorsKatsuro Tachibana, Shunro Tachibana
Life of this patent
Estimating the term…
Abstract
A booster comprising a plurality of microbubbles of a gas in a liquid, e.g. about 4×107 cells/ml of microbubbles of a gas having a diameter of 0.1. to 100 μm in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.
Claims34
A catheter, comprising:
- a flexible elongated member including a lumen, a lumen delivery port, and a distal portion, the elongated member being adapted for intravascular positioning;
- and
- an ultrasonic transducer coupled to the distal portion of the elongated member and generating ultrasound energy, and wherein the lumen is acoustically isolated from the ultrasound energy to permit delivery of microbubbles to a selected tissue site from the lumen delivery port.
A drug administration device for enhancing delivery of a liquid drug solution to a treatment site within a body, comprising:
- an elongated member having a proximal end portion and a distal end portion and formed with a drug delivery lumen extending longitudinally therethrough, said distal end portion of said elongated member being formed for insertion into said treatment site within said body;
- and
- an ultrasonic element disposed on said distal end portion of said elongated member, said ultrasonic element being adapted to direct ultrasound energy into said drug solution for producing cavitation in said drug solution.
A drug administration device for enhancing delivery of a liquid drug solution to a treatment site within a body, said drug solution containing a plurality of microbubbles of a gas, comprising:
- a flexible elongated member having a proximal end portion and a distal end portion and formed with a drug delivery lumen extending longitudinally therethrough, said distal end portion of said elongated member being adapted for insertion into a blood vessel within said body;
- and
- an ultrasonic element disposed on said distal end portion of said elongated member, said ultrasonic element being adapted to direct ultrasound energy into said drug solution for producing cavitation in said drug solution, at least a portion of said lumen being acoustically isolated from said ultrasonic element.
A drug administration system, comprising:
- an elongated member having a proximal end portion and a distal end portion and formed with a drug delivery lumen extending longitudinally therethrough, said distal end portion of said elongated member being formed for insertion into a treatment site within a body;
- a liquid drug solution for treating tissue at said treatment site;
- and
- an ultrasonic element disposed on said distal end portion of said elongated member, said ultrasonic element being adapted to direct ultrasound energy into said drug solution for producing cavitation in said drug solution, wherein said cavitation enhances absorption of said drug solution into said tissue.
A drug administration device for enhancing transdermal administration of a medicament, comprising:
- a transfer member having a top surface and a bottom surface, said bottom surface being adapted for contact with a portion of a patient's skin, said transfer member being permeable to said medicament;
- a cover located over said top surface and forming a chamber between said cover and said top surface,
- a selected quantity of said medicament located within said chamber;
- and
- an ultrasonic element located within said chamber for transmitting ultrasonic energy to said medicament and said skin for enhancing delivery of said medicament across said transfer member into said skin.
A system for treating a selected tissue site with ultrasound energy, comprising:
- an elongated member having a proximal end portion and a distal end portion and formed with a delivery lumen extending longitudinally therethrough, said distal end portion of said elongated member being formed for advancement to said tissue site;
- a liquid composition for delivery through said delivery lumen to said tissue site;
- a plurality of microbubbles of a gas contained within said liquid composition;
- and
- an ultrasonic element disposed on said distal end portion, said ultrasonic element being adapted to direct said ultrasound energy into said liquid composition wherein said microbubbles enhance an effect of said ultrasound energy at said tissue site.
A drug administration device for dissolving a thrombus, comprising:
- an anti-thrombosis agent;
- and
- a base tube containing:
- a first opening for receiving the anti-thrombosis agent;
- a second opening for delivering the anti-thrombosis agent into a patient;
- and
- an ultrasound element adjacent to the second opening vibrating at about 20 kHz to about several MHz and capable of coupling vibrational energy into the anti-thrombosis agent.
A drug administration device for internal administration of a pharmaceutical liquid comprising:
- a base tube containing:
- a first opening for receiving the pharmaceutical liquid;
- a second opening for delivering the pharmaceutical liquid into a patient;
- and
- an ultrasound element adjacent to the second opening capable of coupling vibrational energy into the pharmaceutical liquid to a level sufficient to cause cavitation in the pharmaceutical liquid.
A method of dissolving a thrombus, comprising:
- providing an anti-thrombosis agent;
- providing a drug administration device containing:
- a base tube having first and second openings at opposite ends thereof;
- and
- an ultrasound transducer disposed in an area adjacent to the second opening;
- vibrating the ultrasound element at about 20 kHz to about several MHz;
- introducing the anti-thrombosis agent into the first opening;
- and
- allowing the anti-thrombosis agent to exit the second opening.
A method of administering a pharmaceutical liquid, comprising:
- providing a drug administration device containing:
- a base tube having first and second openings at opposite ends thereof;
- and
- an ultrasonic transducer disposed in an area adjacent to the second opening;
- introducing the pharmaceutical liquid into the first opening;
- allowing the pharmaceutical liquid to exit the second opening;
- and
- vibrating the ultrasound element at a low energy level sufficient to cause cavitation in said liquid.
Dependencies are inferred from the claim text.