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US 6,537,271 B1Granted
Balloon cryogenic catheter
AssigneeCryoGen, Inc.
InventorsDavid R. Murray, Hong Li
Life of this patent
Estimating the term…
Abstract
A method and apparatus for inflating a balloon at a distal portion of an elongated delivery catheter to contact surrounding biological tissue, and expanding a refrigerant adjacent the balloon to cool the biological tissue to render it non-viable. The inflation of the balloon can be accomplished with the expanded refrigerant or with a separate pressurized fluid. The balloon can act as a heat transfer element, or there can be a separate heat transfer element on the catheter adjacent the balloon. The apparatus can be used to perform a dilation procedure, such as angioplasty, in conjunction with cooling of the surrounding tissue.
Claims19
An apparatus for cooling biological tissue in a patient, comprising:
- a source of compressed refrigerant, said source having an inlet and an outlet;
- an elongated delivery element;
- an inflatable balloon affixed to a distal portion of said delivery element;
- a supply conduit on said delivery element, said supply conduit connecting said outlet of said refrigerant source to said distal portion of said delivery element;
- an expansion element connected to a distal portion of said supply conduit for expanding compressed refrigerant;
- and
- a return conduit on said delivery element, said return conduit connected to return expanded refrigerant from an outlet of said expansion element to said inlet of said refrigerant source;
- wherein said delivery element comprises a rigid probe.
5 more elements
An apparatus for cooling biological tissue in a patient, comprising:
- a source of compressed refrigerant, said source having an inlet and an outlet;
- an elongated delivery element;
- an inflatable balloon affixed to a distal portion of said delivery element;
- a supply conduit on said delivery element, said supply conduit connecting said outlet of said refrigerant source to said distal portion of said delivery element;
- an expansion element connected to a distal portion of said supply conduit for expanding compressed refrigerant;
- a return conduit on said delivery element, said return conduit connected to return expanded refrigerant from an outlet of said expansion element to said inlet of said refrigerant source;
- a source of pressurized fluid;
- an inflation conduit on said delivery element, said inflation conduit connecting said pressurized fluid source to the interior of said balloon;
- and
- a heat transfer element mounted on said distal portion of said delivery element;
- wherein said expansion element is positioned to expand refrigerant adjacent to said heat transfer element, thereby applying cooling to surrounding tissue via said heat transfer element;
- and
- wherein said return conduit is connected to return expanded refrigerant from the interior of said heat transfer element to said inlet of said refrigerant source.
10 more elements
An apparatus for cooling biological tissue in a patient, comprising:
- a source of compressed refrigerant, said source having an inlet and an outlet;
- a source of pressurized fluid;
- an elongated flexible catheter;
- at least one inflatable balloon affixed to a distal portion of said catheter;
- an inflation lumen in said catheter, said inflation lumen connecting said pressurized fluid source to the interior of said at least one balloon;
- a heat transfer element mounted on said distal portion of said catheter adjacent said at least one balloon;
- a supply lumen within said catheter, said supply lumen connected to conduct compressed refrigerant from said outlet of said refrigerant source to said distal portion of said catheter;
- an expansion element connected to said supply lumen, said expansion element being positioned to expand compressed refrigerant adjacent to said heat transfer element, thereby applying cooling to surrounding tissue via said heat transfer element;
- and
- a return lumen within said catheter, said return lumen connected to conduct expanded refrigerant from said interior of said heat transfer element to said inlet of said refrigerant source.
7 more elements
A method for cooling biological tissue in a patient, said method comprising:
- providing an elongated delivery element with an inflatable balloon affixed to a distal portion thereof;
- inserting said delivery element and said balloon into a target location within said patient;
- flowing compressed refrigerant through said delivery element;
- inflating said balloon to contact selected biological tissues;
- and
- expanding said refrigerant adjacent said distal portion of said delivery element to cool selected biological tissues;
- wherein:
- said inflation of said balloon comprises conducting a pressurized fluid through an inflation lumen of said delivery element into the interior of said balloon;
- and
- said expansion of said refrigerant cools a heat transfer element on said delivery element adjacent said balloon to cool selected biological tissues.
7 more elements
A method of opening a restricted area of a blood vessel, comprising
- providing an elongated catheter with an inflatable balloon affixed to a distal portion thereof;
- inserting said catheter and said balloon into a target location within said blood vessel;
- inflating said balloon to dilate said blood vessel;
- flowing compressed refrigerant through said catheter;
- expanding said refrigerant adjacent said distal portion of said catheter to cool said dilated portion of said blood vessel;
- wherein:
- said inflation of said balloon comprises conducting a pressurized fluid through an inflation lumen of said catheter into the interior of said balloon;
- and
- said expansion of said refrigerant cools a heat transfer element on said catheter adjacent said balloon to cool said dilated portion of said blood vessel.
6 more elements
A method for opening a restricted area of a blood vessel, comprising:
- providing an elongated catheter with an inflatable balloon affixed to a distal portion thereof;
- inserting said catheter and said balloon into a target location within said blood vessel;
- inflating said balloon to dilate said blood vessel;
- flowing compressed refrigerant through said catheter;
- expanding said refrigerant adjacent said distal portion of said catheter to cool said dilated portion of said blood vessel;
- wherein:
- said inflation of said balloon comprises conducting a pressurized fluid through an inflation lumen of said catheter into the interior of said balloon;
- and
- said expanded refrigerant is conducted into the interior of said inflated balloon, to cool the surface of said balloon to cool said dilated portion of said blood vessel.
6 more elements
A method for rendering non-viable selected biological tissue in a patient, said method comprising:
- inserting an elongated delivery element having an inflatable balloon into the patient;
- inflating said balloon adjacent to the selected biological tissue;
- and
- rendering non-viable said selected biological tissues by cooling at least a portion of said elongated delivery element;
- wherein:
- said elongated delivery element has a metallic coil;
- and
- said cooling is applied to said metallic coil.
5 more elements
A method for rendering non-viable selected biological tissue in a patient, said method comprising:
- inserting an elongated delivery element having an inflatable balloon into the patient;
- inflating said balloon adjacent to the selected biological tissue;
- and
- rendering non-viable said selected biological tissues by cooling at least a portion of said elongated delivery element;
- wherein:
- said elongated delivery element has a metallic tube;
- and
- said cooling is applied to said metallic tube.
5 more elements
A method for rendering non-viable selected biological tissue in a patient, said method comprising:
- inserting an elongated delivery element having an inflatable balloon into the patient;
- inflating said balloon adjacent to the selected biological tissue;
- and
- rendering non-viable said selected biological tissues by cooling at least a portion of said elongated delivery element;
- wherein said inserting comprises inserting an elongated delivery element having a pluralty of inflatable balloons into the patient.
2 more elements
A method for opening a restricted area of a blood vessel, comprising:
- inserting an elongated delivery element having an inflatable balloon into a blood vessel of a patient;
- inflating said balloon to dilate said blood vessel;
- and
- rendering non-viable selected tissues of said blood vessel by cooling at least a portion of said elongated delivery element;
- wherein:
- said elongated delivery element has a metallic coil;
- and
- said cooling is applied to said metallic coil.
5 more elements
A method for opening a restricted area of a blood vessel, comprising:
- inserting an elongated delivery element having an inflatable balloon into a blood vessel of a patient;
- inflating said balloon to dilate said blood vessel;
- and
- rendering non-viable selected tissues of said blood vessel by cooling at least a portion of said elongated delivery element;
- wherein:
- said elongated delivery element has a metallic tube;
- and
4 more elements
Dependencies are inferred from the claim text.