Methods for increasing a cytotoxic T lymphocyte response in vivo
AssigneesThe Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
InventorsEyal Raz, Hearn Jay Cho, Douglas Richman, Anthony A. Horner
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Abstract
The invention provides methods for T helper-independent activation of an antigen-specific cytotoxic T lymphocyte response in an individual. The methods generally involve administering to an individual an immunostimulatory nucleic acid molecule in an amount effective to increase an antigen-specific CTL response in the individual. The invention further provides methods for increasing chemokine secretion, which can block HIV infection.
Claims11
A method of increasing antigen-specific T lymphocyte activity in a CD4+ T cell-deficient individual, comprising administering a formulation comprising an immunostimulatory nucleic acid molecule and an antigen in an amount effective to increase antigen-specific CTL activity, wherein the immunostimulatory nucleic acid is covalently linked to the antigen.
Dependencies are inferred from the claim text.