US 6,518,031 B2 · Hapten-carrier conjugates for treating and preventing nicotine addiction

Abstract

Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality of nicotine in its native (S)-(−) state, and have good stability properties. The conjugates are useful in formulating vaccines for active immunization, that are used to prevent and treat nicotine addiction. The antibodies raised in response to the nicotine hapten-carrier conjugate are used for passive immunization. These antibodies are administered for prevention and treatment of nicotine addiction.

Claims18

Dependent claims

An antibody produced in response to a hapten-carrier conjugate of the following formula:

wherein
m is 1 to 2500,
n is 0 to 12,
y is 1 to 12,
X is selected from the group consisting of NH—CO, CO—NH, CO—NH—NH, NH—NH—CO, NH—CO—NH, CO—NH—NH—CO, and S—S;
Y is selected from the group consisting of NH—CO, CO—NH, CO—NH—NH, NH—NH—CO, NH—CO—NH, CO—NH—NH—CO, and S—S,
and the —(CH2)n—X—(CH2)y—Y— moiety is bonded to the 3′, 4′ or 5′ position of nicotine.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

09/784,139Filed 16 Feb 2001 · division

Priority

1 Dec 1998

Published

US 2002/0004208 A110 Jan 2002

Granted

11 Feb 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61K 39/0013
Medicinal preparations containing antigens or antibodies: therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
A61K 47/646
Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is…: the…
A61P 25/34
For treating abuse or dependence: tobacco-abuse
C07K 16/44
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material not provided for elsewhere , e.g. haptens, metals, DNA, RNA,…

Hapten-carrier conjugates for treating and preventing nicotine addiction

Life of this patent

Hapten-carrier conjugates for treating and preventing nicotine addiction

Life of this patent

Abstract

Claims18