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US 6,494,613 B2Granted
Apparatus and method for mixing materials sealed in a container under sterile conditions
AssigneeLevTech, Inc.
InventorAlexandre Terentiev
Life of this patent
Estimating the term…
Abstract
A mixing bag usable in chemical and bioprocessing procedures that is hermetically sealed about a tube that is closed within the bag but extends out through a seal and adapted to receive a rotatable rigid rod of a predetermined shape for mixing the materials in the bag.
Claims16
An apparatus for mixing materials into final non-contaminated product comprising:
- a container containing said materials under sterile conditions;
- an annularly shaped seal positioned in an opening into said container;
- a flexible tube extending through said seal into said container and having a hermetically sealed relationship with said seal, said tube being closed within said container and having an open distal end outside of said container;
- a substantially rigid rod positioned within and spaced apart from said tube, said rod have a predetermined shape and substantially spanning the length of said tube within said container;
- and
- a motor detachably secured to one end of said mixing rod for rotating said shaft to thereby mix said materials within said container.
3 more elements
A hermetically sealed article of manufacture for containing materials under sterile conditions and permitting mixing of such materials comprising
- a container containing said materials and having at least one opening;
- an annularly shaped sealed positioned in said opening;
- and
- a flexible tube extending through said opening into said container, said tube being closed within said container and having an open distal end outside of said container, said tube further being provided with a multiplicity of spaced apart annularly shaped inserts along its length and adapted to receive a rigid rod therethrough.
1 more element
A method of mixing materials within a container under sterile conditions including the steps of
- providing a container with an annularly shaped seal in an opening in said container;
- placing a closed portion of a flexible tube with annularly shaped inserts spaced along the interior of the tube through said seal and into said container in an hermetically sealed relationship with said seal so that the open end of said tube is outside of said container;
- feeding a rigid rod of a predetermined shape through the open end of the tube into said tube through the annular spacers along the length thereof in a spaced apart relationship with said tube and leaving a free distal end of said rod outside of said tube;
- clamping said tube to hold said tube stationary at the point;
- and
- rotating said rod to cause movement of said tube within said container thereby mixing the materials contained in said container.
3 more elements
Dependencies are inferred from the claim text.