Modulation of cholesteryl ester transfer protein (CETP) activity
AssigneeAvant Immunotherapeutics, Inc.
InventorCharles W. Rittershaus
Life of this patent
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Abstract
This invention relates to peptides comprising a helper T cell epitope portion and a B cell epitope portion for eliciting an immune response against endogenous cholesteryl ester transfer protein (CETP) activity, to prevent or treat cardiovascular disease, such as atherosclerosis.
Claims26
An isolated antigenic hybrid peptide comprising a helper T cell epitope portion linked to a B cell epitope portion, wherein said B cell epitope portion comprises six to 26 consecutive amino acids of the carboxyl terminal 26 amino acids of human cholesteryl ester transfer protein (SEQ ID NO:1).
An isolated antigenic hybrid peptide comprising the amino acid sequence of SEQ ID NO:2.
A vaccine composition comprising an antigenic vaccine hybrid peptide comprising a universal helper T cell epitope linked to a B cell epitope portion comprising six to 26 consecutive amino acids of the carboxyl terminal 26 amino acids of human cholesterol ester transfer protein (SEQ ID NO:1).
A method of elevating the ratio of circulating High Density Lipoprotein to circulating Low Density Lipoprotein, Very Low Density Lipoprotein, or total cholesterol in a human or other animal comprising administering to the human or animal an antigenic vaccine hybrid peptide comprising a universal helper T cell epitope portion and a B cell epitope portion. wherein said B cell epitope portion comprises six to 26 consecutive amino acids of the carboxyl terminal 26 amino acids of human cholesteryl ester transfer protein (SEQ ID NO:1).
A method of decreasing the level of cholesteryl ester transfer protein activity in a human or other animal comprising administering to the human or animal an antigenic vaccine hybrid peptide comprising a helper T cell epitope portion linked to a B cell epitope portion comprising six to 26 consecutive amino acids of the carboxyl terminal 26 amino acids of human cholesterol ester transfer protein (SEQ ID NO:1).
A method of increasing the level of circulating High Density Lipoprotein in a human or other animal comprising administering to the human or animal an antigenic vaccine hybrid peptide comprising a helper T cell epitope portion and a B cell epitope portion, wherein said B cell epitope portion comprises six to 26 consecutive amino acids of the carboxyl terminal 26 amino acids of human cholesterol ester transfer protein (SEQ ID NO:1).
A method of treating atherosclerosis in a human or animal comprising administering to the human or animal an antigenic vaccine hybrid peptide comprising a universal helper T cell epitope portion linked to a B cell epitope portion, wherein said B cell epitope portion comprises six to 26 consecutive amino acids of the carboxyl terminal 26 amino acids of human cholesteryl ester transfer protein.
A method of making an anti-cholesteryl ester transfer protein (CETP) vaccine comprising a B cell epitope portion and a helper T cell epitope portion to modulate endogenous CETP activity, comprising:
- selecting a B cell epitope portion from a region of CETP involved in neutral lipid binding or neutral lipid transfer activity;
- selecting a helper T cell epitope portion consisting of a helper T cell epitope;
- and
- linking said B cell epitope portion and said helper T cell epitope portion to form a single immunogenic moiety.
Dependencies are inferred from the claim text.