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US 6,403,759 B2Granted
Polymers for delivering nitric oxide in vivo
AssigneeDuke University
InventorsJonathan S. Stamler, Eric J. Toone, Richard S. Stack
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AssigneeDuke University
InventorsJonathan S. Stamler, Eric J. Toone, Richard S. Stack
Estimating the term…
Disclosed are novel polymers derivatized with at least one —SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized-S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by the following structural formula: R is an organic radical. Each X′ is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each X′ is the same and is a C2-C6 alkylene group, more preferably—CH2—, —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2—. p and m are independently a positive integer such that p+m is greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.
A polymer derivatized with at least one —SNO group per 1200 atomic mass units of the polymer.
An article capable of releasing NO wherein the article is coated with a polymer comprising at least one —SNO group per 1200 amu of the polymer.
A method of delivering nitric oxide to a treatment site in a subject or to a bodily fluid comprising the steps of:
A method of preparing an article capable of releasing NO comprising coating an article with at least one —SNO group per 1200 amu of the polymer.
A method of replacing a loss of NO groups from an S-nitrosylated polymer, said method comprising the step of contacting the S-nitrosylated polymer with an effective amount of a gaseous nitrosylating agent.
Dependencies are inferred from the claim text.