Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
AssigneeGenentech, Inc.
InventorsNapoleone Ferrara, Sophia S. Kuo
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Abstract
The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E is shown herein to induce enhanced survival of cells, proliferation of cells and hypertrophy of cells. Thus, VEGF-E can be useful in wound repair, as well as the generation and regeneration of tissue.
Claims6
A VEGF-E polypeptide comprising an amino acid sequence at least about 80% identical to the sequence of SEQ ID NO:2, wherein the VEGF-E polypeptide has the biological activity of promoting selective growth and/or survival of human umbilical vein endothelial cells (HUVEC) in an in vitro assay.
Dependencies are inferred from the claim text.