Packing material for liquid chromatography and process for producing the same

Abstract

Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof. A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 μm, said granules being composed of crystalline particles with an average size of from 0.1 to 10 μm. A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca10(PO4)6(OH)2, Ca3(PO4)2, Ca2P2O7, Ca(PO3)2, Ca10(PO4)6F2 and Ca10(PO4)6Cl2, said packing material having a dense structure with a porosity of no more than 5%. A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I): Ca10(PO4)6(OH)2−2xF2x  (I) wherein x is a number of from about 0.1 to 1.

Dependencies are inferred from the claim text.