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AssigneeThe Rockfeller University
InventorsTitia DeLange, Dominique Broccoli, Agata Smogorzenska
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The present invention relates to a novel nucleotide sequence encoding a telomeric protein which binds a repeat region of telomeric sequences, and to the protein encoded thereby. Also included within the invention are expression vectors for the production of the telomeric protein and host cells transformed with the nucleotide sequence. In addition, antibodies, probes and antagonists specific for the telomeric protein are contemplated. Methods of identifying antagonists of the telomeric protein, diagnostic methods of identifying the telomeric protein in a sample, and therapeutic uses of the telomeric protein, particularly in the treatment of aging and cancer, are also contemplated.
A vertebrate telomere repeat binding factor 2 (TRF2) obtained by expressing a nucleic acid operatively linked to an expression control sequence in a cell;
An isolated vertebrate telomere repeat binding factor (TRF) comprising an amino acid sequence that is at least 80% identical to that of SEQ ID NO:27, and comprising the following characteristics:
An isolated protein comprising the basic N-terminal domain of a vertebrate telomere repeat binding factor 2 (TRF2) that has the amino acid sequence of SEQ ID NO:37, or an amino acid sequence that is at least 80% identical to that of SEQ ID NO:37;
An isolated protein comprising a dimerization domain of a vertebrate telomere repeat binding factor 2 (TRF2) that comprises the amino acid sequence of SEQ ID NO:45, or an amino acid sequence that is at least 80% identical to that of SEQ ID NO:45;
An isolated protein that is a truncated vertebrate telomere repeat binding factor 2 (TRF2) that has the amino acid sequence of SEQ ID NO:31 or an amino acid sequence that is at least 80% identical to that of SEQ ID NO:31;
An antibody that recognizes a basic N-terminal domain of a vertebrate telomere repeat binding factor 2 (TRF2) that has the amino acid sequence of SEQ ID NO:37, or an amino acid sequence that is at least 80% identical to that of SEQ ID NO:37;
An antibody raised against a vertebrate telomere repeat binding factor2 (TRF2) comprising an amino acid sequence that is at least 80% identical to that of SEQ ID NO:27;
An antibody raised against a vertebrate telomere repeat binding factor 2 (TRF2) dimerization domain consisting essentially of an amino acid sequence that is at least 80% identical to that of SEQ ID NO:45;
An isolated fragment of a vertebrate telomere repeat binding factor 2 (TRF2) consisting of 30 to 90 amino acids;
An isolated fragment of a vertebrate telomere repeat binding factor 2 (TRF2);
Dependencies are inferred from the claim text.