Substituted derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II

Compounds of formula I

• wherein
• A denotes oxygen, sulphur or NH,
• R1 denotes an optionally unsaturated alkyl or alkyloxyalkyl group, optionally mono- or polysubstituted or mixed substituted by halogen, alkoxy, oxo or cyano, a cycloalkyl, aryl or heteroaryl group optionally mono- or polysubstituted or mixed substituted by halogen, alkyl, CF3, cyano or alkoxy,
• R2 and R3, independently from one another, denote hydrogen, an optionally polyfluorinated alkyl group, an aralkyl, aryl or heteroaryl group or a group (CH2)n—X, or R2 and R3, together with the N- atom denotes a 3- to 7- membered saturated, partially or completely unsaturated heterocycle with one or more heteroatoms N, O or S, which may optionally be substituted by oxo, an alkyl, alkylaryl or aryl group, or a group (CH2)n—X, X denotes halogen, NO2, —OR4, —COR4, —CO2R4, —OCO2R4, —CN, —CONR4OR5, —CONR4R5, SR4, —S(O)R4, —S(O)2R4, —NR4R5, —NCH(O)R4, NHS(O)2R4,
• n is a whole number from 0 to 6,
• R6 denotes a straight-chained or branched alkyl group with 1-10 C-atoms, a vinyl group, a cycloalkyl group, an alkylene carboxyl group, an aryl group, aralkyl group, a heteroaryl or beteroaralkyl group, which may optionally be substituted by halogen or alkoxy,
• R7 denotes hydrogen, halogen, hydroxy, a straight-chained or branched alkyl, alkoxy, acyloxy or alkyloxycarbonyl group with 1-6 C-atoms, which may optionally be mono- or polysubstituted by halogen, —NO2, —OR4, —COR4, —CO2R4, —OCO2R4, —CN, —CONR4OR5, —CONR4R5, —SR4, —S(O)R4, —S(O)2R4, —NR4R5, —NHC(O)R4, —NHS(O)2R4, or a polyfluoroalkyl group, R4 and R5, independently from one another, denote hydrogen, alkyl, aralkyl or aryl, and
• m is a whole number from 0 to 2,
• and the pharmaceutically-acceptable salts thereof.