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US 6,297,257 B1Granted
Benzazine derivatives phosphodiesterase 4 inhibitors
AssigneeZambon Group S.p.A.
InventorsMauro Napoletano, Gabriele Norcini, Daniela Botta, Giancarlo Grancini, Gabriele Morazzoni
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Abstract
Compounds of formula (I) wherein A is an orthocondensed heterocycle optionally substituted by certain substituents and necessarily substituted by a —B—Cy group where the variables are as defined in the specification and the N→O derivatives and pharmaceutically acceptable salts thereof are phosphodiesterase-4 inhibitors.
Claims6
A compound of formula I
- wherein A is
- wherein
- A is substituted by a —B—Cy group wherein B is methylene, ethylene, amino, CONH or a bond and Cy is a 5- or 6-membered heterocycle containing from 1 to 3 nitrogen atom(s) optionally substituted by one or more halogen(s), and A is optionally substituted by (C1-4)alkyl, (C1-4)alkoxy or COOR′, wherein R′ is hydrogen or a (C1-4)alkyl group
- R1 is a (C1-6)alkyl or polyfluoro(C1-6)alkyl group;
- R2 is aryl, aryl-(C1-10)-alkyl or a (C4-7)cycloalkyl group optionally containing an oxygen atom and optionally substituted by a polar substituent;
- and the N→O derivatives and pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.