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US 6,297,241 B1Granted
Carbamate derivatives of diaryl 1,3,4-oxadiazolone
AssigneeBristol-Myers Squibb Company
InventorsPiyasena Hewawasam, Xi Chen, John E. Starrett
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Abstract
The present invention provides novel carbamate oxadiazolone derivatives having the general formula wherein R1 and R2 are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of the large conductance calcium-activated potassium channels.
Claims7
A compound of the formula
- wherein
- R2 is hydrogen or C1-4 alkyl;
- or R1 and R2 taken together with the nitrogen atom to which they are attached is
- and
- R7, R8 and R9 each are independently C1-4 alkyl;
- in which
- is a counter anion thereof.
4 more elements
A compound selected from the group consisting of:
- [[[4-chloro-2-[[5-[4-(trifluoromethyl)phenyl]2,3-dihydro-2-oxo-1,3,4-oxadiazol-3-yl]methyl]phenyoxy]carbonyl]3-amino]propionic acid;
- 3-[[5-chloro-2-[[[[2-(methylamino)ethyl]methylamino]carbonyl]oxy]-phenyl]methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one;
- and 3-[[5-chloro-2-[[[morpholin-4-yl]carbonyl]oxy]phenyl]methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadizaol-2(3H)-one;
- or a non-toxic pharmaceutically acceptable salt or solvate thereof.
1 more element
Dependencies are inferred from the claim text.