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AssigneeAmerican Home Products Corporation
InventorsAmedeo A. Failli, David K. Williams, Thomas J. Caggiano, Jay S. Shumsky, Mark A. Ashwell
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The present invention provides compounds of the general formula: wherein Y is a moiety selected independently, from NH or —(CH2)n— wherein n is 1; m is an integer from 1 to 2; and the moiety represents: (1) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen (wherein A is nitrogen, and B and C are CH), (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen (wherein A is carbon, B is nitrogen, and C is —CH—CH—), (3) a 6-membered aromatic (unsaturated) ring (wherein A is carbon, B is CH, and C is —CH—CH—); as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination.
A compound which is selected from the group of
A method of treating urinary disorders in a mammal selected from the group of diabetes insipidus, nocturnal enuresis, nocturia or urinary incontinence, the method comprising administering to the mammal in need thereof a pharmaceutically effective amount of a compound of the formula:
A method of promoting temporary delay of urination in a mammal, the method comprising administering to the mammal in need thereof a pharmaceutically effective amount of a compound of the formula:
Dependencies are inferred from the claim text.