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US 6,297,230 B1Granted
Cyanoaziridines for treating cancer
AssigneeAmpliMed Corporation
InventorsWilliam A. Remers, Evan M. Hersh, Robert T. Dorr, Bhashyam Iyengar
Life of this patent
Estimating the term…
Abstract
The present invention is directed to novel anti-cancer compounds of the formula. wherein X is CN, R4 is hydrogen or lower alkyl; and R5 is lower alkyl, lower cycloalkyl, alkenyl, alkynyl, aryl, monosubstituted aryl, disubstituted aryl, aryl lower alkyl, lower alkoxycarbonyl lower alkyl, or heterocyclic ring, with the proviso that when X is CN, and R4 is hydrogen, then R5 is not CH3, C6H5, or, p-nitrophenyl. R4, R5 and N taken together form a heterocyclic ring.
Claims13
A compound of the formula 1:
- wherein X is CN;
- wherein R4 is hydrogen or lower alkyl of 1-4 carbons;
- and, wherein R5 is an alkyl of 1-8 carbons, lower cycloalkyl of 4-7 carbons, alkenyl of 1-6 carbons, an aryl of 4-10 carbons, a substituted aryl of 4-12 carbons, a heterocyclic group of 4-16 members, with the proviso that when X is CN, and R4 is hydrogen, then R5 is not CH3, C6H5, or, p-nitrophenyl.
Dependencies are inferred from the claim text.