Acyl deoxyribonucleoside derivatives and uses thereof
AssigneePro-Neuron, Inc.
InventorsReid Warren von Borstel, Michael Kevin Bamat
Life of this patent
Estimating the term…
Abstract
The invention relates to compositions comprising acyl derivatives of 2′-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.
Claims24
An acyl derivative of 2′-deoxyadenosine, having the formula
- wherein R1, R2, and R3 are the same or different and each is hydrogen or an acyl group derived from
- (a) an unbranched fatty acid with 3 to 22 carbon atoms,
- (b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine, provided that R2 is not derived from leucine and that R3 is not derived from glycine or threonine,
- (c) nicotinic acid, or
- (d) a dicarboxylic acid having 3 to 22 carbon atoms,
- provided that not all of R1, R2, and R3 are H, and where R3 is not H, then R1 and/or R2 may also be acetyl, or a pharmaceutically acceptable salt thereof.
An acyl derivative of 2′-deoxyguanosine having the formula
- wherein R1, R2, and R3 are the same or different and each is hydrogen or an acyl group derived from
- (a) an unbranched fatty acid with 3 to 22 carbon atoms, provided that when R3 is H, R1 and R2 are not both derived from butyryl,
- (b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, phenylalanine, carnitine, and ornithine,
- (c) nicotinic acid, or
- (d) a dicarboxylic acid having 3 to 22 carbon atoms,
- provided that not all of R1, R2, and R3 are H, and where R3 is not H, then R1 and/or R2 may also be acetyl, or a pharmaceutically acceptable salt thereof.
An acyl derivative of 2′-deoxycytidine, having the formula
- wherein R1, R2, and R3 are the same or different and each is hydrogen or an acyl group derived from
- (a) an unbranched fatty acid with 3 to 22 carbon atoms,
- (b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,
- (c) nicotinic acid, or
- (d) a dicarboxylic acid having 3 to 22 carbon atoms,
- provided that not all of R1, R2, and R3 are H, and where R3 is not H, then R1 and/or R2 may also be acetyl, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising an effective amount of each of at least two compounds selected from at least two of the groups of compounds having the formulae:
- wherein R1, R2, and R3 are the same or different and each is H or an acyl group derived from a carboxylic acid, provided that at least one of said substituents R1, R2, and R3 on each of said groups of compounds is not hydrogen, or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.