Antimicrobial cationic peptides
AssigneeThe University of British Columbia
InventorsRobert E. W. Hancock, Nedra Karunaratne
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Abstract
A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH2-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH2-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
Claims5
A method of treating an endotoxemia or sepsis associated disorder in a subject having or at risk of having such a disorder, comprising administering to the subject a therapeutically effective amount of a peptide having an amino acid sequence selected from the group consisting of:
- NH2-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1),
- NH2-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2),
- NH2-KWKSFIKNLTKGGSKILTTGLPALIS-COOH (SEQ ID NO:3),
- NH2-KWKKFIKNLTKGGSKILTTGLPALIS-COOH (SEQ ID NO:4),
- NH2-KWKSFIKNLEKVLKPGGLLSNIVTSL-COOH (SEQ ID NO:5),
- NH2-KWKSFIKNLEKVLKKGPILANLVSIV-COOH (SEQ ID NO:6),
- NH2-KWKEFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:7),
- NH2-KWKKFIKELQKVLAPGGLLSNIVTSL-COOH (SEQ ID NO:8),
- NH2-KWKSFIKKLTSVLKKVVTTALPALIS-COOH (SEQ ID NO:9),
- NH2-KWKSFIKNLTKVLKKVVTTALPALIS-COOH (SEQ ID NO:10),
- NH2-KWKLFKKKGTGAVLTVLTTGLPALIS-COOH (SEQ ID NO:11),
- NH2-KWKSFIKKLTSVLKKVVTTAKPLISS-COOH (SEQ ID NO:12),
- NH2-KKKSFIKLLTSAKVSVLTTAKPLISS-COOH (SEQ ID NO:13),
- NH2-KWKKFIKELQKVLKPGGLLSNIVTSL-COOH (SEQ ID NO:14),
- NH2-KKWWRRVLSGLKTGPALSNV-COOH (SEQ ID NO:15),
- NH2-KKWWRRVLKGLSSGPALSNV-COOH (SEQ ID NO:16),
- NH2-KKWWRRALQALKNGPALSNV-COOH (SEQ ID NO:17),
- NH2-KKWWRRVLSGLKTAGPAIQSVLNK-COOH (SEQ ID NO:18),
- NH2-KKWWRRALQGLKTAGPAIQSVLNK-COOH (SEQ ID NO:19),
- NH2-KKWWKAQKAVNSGPNALQTLAQ-COOH (SEQ ID NO:20)
- NH2-KKWWKAKKFANSGPNALQTLAQ-COOH (SEQ ID NO:21), and
- NH2-KKWWKFIKKAVNSGTTGLQTLAS-COOH (SEQ ID NO:22).
Dependencies are inferred from the claim text.