US 6,297,051 B1 · MN gene and protein

Abstract

Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for pre-neoplastic/neoplastic disease to detect or detect and quantitate such abnormal MN gene expression. Also disclosed are methods to treat pre-neoplastic/neoplastic disease involving the MN gene and protein, e.g., methods comprising the use of MN-specific antibodies, anti-idiotype antibodies thereto, and anti-anti-idiotype antibodies, and the use of MN antisense nucleic acids. Further disclosed are methods to identify and block MN binding site(s) and identify MN protein partners(s).

Claims14

Dependent claims

A method of inhibiting the growth of a vertebrate preneoplastic or neoplastic cell that is abnormally expressing MN protein comprising contacting that cell with a polypeptide composed of 50 or less amino acids, wherein said polypeptide specifically binds to a site on the MN protein to which vertebrate cells adhere in a cell adhesion assay;

wherein said polypeptide when tested in vitro inhibits the adhesion of vertebrate cells to said MN protein;
and wherein said polypeptide comprises a peptide selected by screening a phage display peptide library for specific binding to said MN protein.

Dependencies are inferred from the claim text.

Facts

Application

09/177,776Filed 23 Oct 1998 · continuation in part

Priority

24 Jan 1997

Granted

2 Oct 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

G01N 33/502
For testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics: for testing non-proliferative effects
A61K 38/08
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides having 5 to 11 amino acids
A61P 35/00
Antineoplastic agents
G01N
Investigating or analysing materials by determining their chemical or physical properties

MN gene and protein

Life of this patent

MN gene and protein

Life of this patent

Abstract

Claims14