N-end rule pathway enzymes
AssigneeE. I. Du Pont de Nemours and Company
InventorsRebecca E. Cahoon, Saverio Carl Falco, J. Antoni Rafalski, Hajime Sakai
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Abstract
This invention relates to an isolated nucleic acid fragment encoding an enzyme involved in the N-end rule pathway of protein degradation. The invention also relates to the construction of a chimeric gene encoding all or a portion of the enzyme involved in the N-end rule pathway of protein degradation, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the enzyme involved in the N-end rule pathway of protein degradation in a transformed host cell.
Claims14
An isolated polynucleotide that encodes an arginyl-tRNA-protein transferase, the polypeptide having a sequence identity of at least 80%, based on the Clustal method of alignment, when compared to a polypeptide selected from the group consisting of SEQ ID NOs:2 and 4.
Dependencies are inferred from the claim text.