US 6,297,031 B1 · Escherichia coli strain and method for producing L-threonine

Escherichia coli strain and method for producing L-threonine

AssigneeAjinomoto Co., Inc.

InventorsVladimir Georgievich Debabov, Jury Ivancvich Kozlov, Evgeny Mciseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Christoserdov, Tatyana Grigorievna Plotnikova, Irina Clegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova

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Abstract

E. coli strains derived form E. coli strain VNIIgenetika 472t23 and obtained by a process involving transduction by bacteriophage P1 which bears a transposon which inactivates threonine dehydrogenase activity and isolation of a transductant lacking threonine dehydrogenase activity are useful for producing L-threonine.

Claims6

Dependent claims

An E. coli strain which produces L-threonine, derived from E. coli strain VNIIgenetika 472T23 and obtained by a process comprising the steps of transduction by bacteriophage P1 which bears a transposon which inactivates threonine dehydrogenase activity and isolation of a transductant lacking threonine dehydrogenase activity.

Dependencies are inferred from the claim text.

Facts

Application

09/598,451Filed 22 Jun 2000 · continuation

Priority

22 Apr 1992

Granted

2 Oct 2001

Term ends

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Classification7 codes

C12N 1/205
Bacteria; Culture media therefor: bacterial isolates
C12N 15/70
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression: vectors or expression systems…
C12P 13/08
Alpha- or beta- amino acids: lysine; Diaminopimelic acid; Threonine; Valine
C12R 2001/19
Escherichia: escherichia coli

Family

PCT/SU88/00207Parent of this division · filed 25 Oct 1988

Application07/872,141Parent of this continuation · filed 22 Apr 1992

Application08/336,563Parent of this continuation · filed 9 Nov 1994

Application08/430,455Parent of this continuation · filed 28 Apr 1995

Application08/633,028Parent of this continuation · filed 16 Apr 1996

Application08/890,199Parent of this continuation · filed 9 Jul 1997

Application09/390,701Parent of this continuation · filed 7 Sep 1999

US 6,165,756 AParent of this continuation

US 5,976,843 AParent of this continuation

US 5,705,371 AParent of this continuation

US 5,631,157 AParent of this continuation

US 5,538,873 AParent of this continuation

Application07/872,141Parent of this division

Application07/499,278Parent of this division

US 5,175,107 AParent of this division

US 6,297,031 B1This patent

From the US filing history. Foreign family members aren’t listed.