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US 6,296,870 B1Granted
Liposomes containing active agents
AssigneeDuke University
InventorsDavid Needham, Ranjit S. Sarpal
Life of this patent
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Abstract
Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the liposome, and/or entrapped within the liposome interior space in a micellar preparation are described. Methods of making such liposomes are presented.
Claims10
A liposome containing an active agent, wherein the lipid bilayer of the liposome comprises:
- a) phospholipid;
- b) an active agent associated with the lipid bilayer;
- c) surfactant with a Critical Micelle Concentration (CMC) of about 1 millimolar or less, said surfactant contained in the lipid bilayer in an amount sufficient to increase the amount of active agent associated with the lipid bilayer, compared to that amount of active agent that would associate with the lipid bilayer in the absence of surfactant, wherein the active agent is aggregated with said surfactant to form micelles;
- and
- d) from 3 mole percent to 60 mole percent of cholesterol present in the lipid bilayer in an amount sufficient to protect against the disruptive effects of the surfactant contained in the lipid bilayer,
- wherein the lipid bilayer is unilaminar.
3 more elements
Dependencies are inferred from the claim text.