Antimicrobial fabric and medical graft of the fabric

A method of making a medical graft comprising:

• (a) providing porous fabric treated with ceramic particles bound to the fabric material, the particles comprising antimicrobial metal cations ion-exchanged thereon, wherein the process results in some or all of the ceramic particles being exteriorly exposed to permit entry of water and cations into the ceramic particles, thereby effecting an ion exchange reaction, which releases antibiotic cations from the ceramic particles in an antimicrobially effective amount;
• and
• (b) forming said fabric piece into a generally tubular shape to form said graft with said antibiotic agent.

A pliable antimicrobial fabric comprising a porous fabric comprising an antimicrobial metal ion-generating inorganic antimicrobial agent on fibers of the fabric, with the pores of the fabric left open.

A porous, flexible medical graft comprising fabric material formed in a generally tubular shape, wherein at least a portion of the fabric material is coated with a polymeric coating material incorporating inorganic ceramic particles, such that some or all of the ceramic particles are exteriorly exposed to release antibiotic metal cations in an antimicrobially effective amount when the medical graft is implanted in vivo.