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US 6,296,832 B1Granted
Molecules that home to a selected organ in vivo
AssigneeThe Burnham Institute
InventorsErkki Ruoslahti, Renata Pasqualini
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Abstract
The present invention provides enriched library fractions containing a plurality of molecules that home to a selected organ in vivo.
Claims10
An enriched library fraction containing a plurality of molecules that selectively home to a selected organ or tissue, said enriched library fraction recovered by in vivo panning, comprising the steps of:
- a) administering to a subject a library of diverse molecules, wherein each of said molecules is attached to a tag that facilitates recovery of said molecules;
- b) collecting a sample of the selected organ or tissue;
- and
- c) recovering from said sample said enriched library fraction containing a plurality of molecules that selectively home to said selected organ or tissue,
- wherein said library of diverse molecules is not a nucleic acid library.
2 more elements
An enriched library fraction containing a plurality of molecules that target the vasculature of a selected organ or tissue, said enriched library fraction recovered by in vivo panning, comprising the steps of:
- a) administering to a subject a library of diverse molecules, wherein each of said molecules is attached to a tag that facilitates recovery of said molecules;
- b) collecting a sample of the selected organ or tissue;
- and
- c) recovering from said sample said enriched library fraction containing a plurality of molecules that target the vasculature of said selected organ or tissue,
- wherein said library of diverse molecules is not a nucleic acid library.
2 more elements
Dependencies are inferred from the claim text.