Stimulus sensitive gel with radioisotope and methods of making

A method of making a radioisotope carrier, comprising the steps of:

• (a) mixing an acrylamide derivative with a hydrophilic comonomer in a reaction solvent with an initiator forming a reaction mixture;
• (b) copolymerizing the reaction mixture and forming a first linear random copolymer having a plurality of linear chains having a plurality of molecular weights;
• (c) isolating and purifying the copolymerized first linear random copolymer and obtaining a second linear random copolymer having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff;
• (d) mixing the thermally reversible copolymer with an aqueous solvent and making a reversible gelling solution;
• and
• (e) adding an aqueous insoluble or confined radioisotope and obtaining said radioisotope carrier.

A biodegradable thermally reversible stimulus-sensitive gelling copolymer radioisotope carrier, comprising:

• (a) a biodegradable polymer backbone;
• grafted with
• (b) a side chain selected from the group consisting of homo-oligomers of [meth-]acrylamide derivatives, co-oligomers of [meth-]acrylamide derivatives, homo-oligomers of [meth-]acrylamide derivatives copolymerized with hydrophilic comonomers, co-oligomers of [meth-]acrylamide derivatives copolymerized with hydrophilic comonomers;
• mixed with
• (c) an aqueous solvent;
• and
• (d) an aqueous insoluble or confined radioisotope.

A method of making a biodegradable thermally reversible stimulus-sensitive gelling copolymer radioisotope carrier, comprising the steps of:

• (a) polymerizing a plurality of side chains selected from the group consisting of homo-oligomers of [meth-]acrylamide derivatives, co-oligomers of [meth-]acrylamide derivatives, homo-oligomers of [meth-]acrylamide derivatives copolymerized with hydrophilic comonomers, co-oligomers of [meth-]acrylamide derivatives copolymerized with hydrophilic comonomers, said side chain having a first active group;
• (b) coupling the side chains to a biodegradable backbone having a plurality of second active groups wherein said first active group connects to one of the plurality of the second active groups;
• (c) mixing the biodegradable copolymer with an aqueous solvent;
• and
• (d) adding an aqueous insoluble or confined radioisotope.

A method of treating cancer tumors, comprising the steps of:

• (a) mixing a stimulus-sensitive gelling polymer with an aqueous solvent as a stimulus-sensitive gelling solution;
• (b) mixing an aqueous insoluble or confined radioisotope with said stimulus-sensitive gelling solution as said radioisotope carrier;
• and
• (c) injecting said radioisotope carrier into a tumor, said tumor providing a stimulus sufficient for gelling said radioisotope carrier.