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US 6,294,694 B1Granted
Matrix metalloproteinase inhibitors and method of using same
AssigneeWisconsin Alumni Research Foundation
InventorsDonald T. Witiak, Paul J. Bertics, Yingsheng Zhang
Life of this patent
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Abstract
Peptoid compounds of Formula I and Formula II are disclosed The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.
Claims28
A compound having a structure as shown in Formula I or Formula II:
- wherein R1 is selected from the group consisting of H, C1-12-alkyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-12-alkyl, amino-C1-12-alkyl, N—C1-6-alkylamino-C1-12-alkyl, N,N-di-C1-6-alkylamino-C1-12-alkyl,
- and
- wherein R5 and R6 are independently selected from the group consisting of H, C1-6-alkyl, C1-6-alkylthio, C1-6-alkoxy, fluoro, chloro, bromo, iodo, and nitro;
- and X is halo;
- wherein R4 is selected from the group recited above for R1, and R7 is selected from the group consisting of
- R2 and R3 are selected from the group consisting of
- wherein R5 and R6 are as described above;
- and pharmaceutically-suitable salts thereof.
5 more elements
Dependencies are inferred from the claim text.