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US 6,294,692 B1Granted
Process for producing N-formylleucine of high purity
AssigneeIsochem
InventorsPatricia Hussenet, Philippe Le Goff, Gérard Sennyey, Charles-Henry Vincent
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Abstract
A process for producing N-formylleucine includes reacting leucine with formamide, precipitating the N-formylleucine, once the reaction is complete, at a temperature of approximately 0° to 40° C., by mixing the reaction medium with water and an acid, so that the final pH of the mixture is approximately 2 to 3, wherein the amount of water used in between approximately 1.5 and 5 parts per part by weight of starting formamide.
Claims10
Process for producing N-formylleucine, comprising:
- reacting leucine with formaldehyde in the presence of formic acid;
- precipitating the N-formylleucine, once the reaction is complete, at a temperature of approximately 0° to 40° C., by mixing the reaction medium with water and an acid, so that the final pH of the mixture is approximately 2 to 3, wherein the amount of water used when mixing the reaction medium is between approximately 1.5 and 5 parts per part by weight of starting formamide.
Dependencies are inferred from the claim text.