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US 6,294,663 B1Granted
Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
AssigneeBoard of Trustees of the University of Arkansas
InventorsTimothy J. O'Brien, Lowell J. Underwood
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Abstract
The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
Claims9
A DNA encoding Tumor Associated Differentially-Expressed Gene-12 protein selected from the group consisting of:
- (a) an isolated DNA having a sequence of SEQ ID NO:1 or 3 which encodes a TADG-12 protein;
- and
- (b) an isolated DNA differing from the isolated DNA of (a) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-12 protein having a sequence of SEQ ID NO:
- 2 or 4.
1 more element
Dependencies are inferred from the claim text.