Treatment of neurodegenerative diseases
AssigneeApplied Genetics Incorporated Dermatics
InventorDavid A. Brown
Life of this patent
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Abstract
Disclosed are methods for increasing the differentiation of mammalian neuronal cells for purposes of treating neurodegenerative diseases or nerve damage by administration of various compounds including alcohols, diols and/or triols and their analogues.
Claims20
A method for increasing the differentiation of mammalian neuronal cells to a statistically significant level above background, which comprises administering to mammalian cells in need of such increase a pharmaceutical composition comprising an effective amount of one or more diols having the following structure:
- wherein
- each R is independently selected from hydrogen;
- halogen;
- a group containing from one atom to twenty atoms, one of which is carbon, nitrogen, oxygen, or sulfur;
- hydroxyl;
- hydroxymethyl;
- —(CH2)nOH;
- —(CH2)nOR′;
- —(CH2)n—CH(OH)—CHOH;
- —(CH2)n—CH(OH)—CH(OH)R′;—(CH2)n—CH(OH)—(CH2)n—CH2(OH);
- —(CH2)n—CH(OH)—(CH2)n—CH(OH)R′;
- or —CH2OR′;
- wherein each n is independently an integer from 0-25;
- each R′ is independently selected from hydrogen or an acyl or amino acyl group containing from one atom to twenty atoms, at least one of which is carbon, nitrogen, oxygen, or sulfur;
- or pharmaceutically acceptable salts thereof, and
- a pharmaceutically suitable carrier.
A pharmaceutical composition for increasing the differentiation of mammalian neuronal cells to a statistically significant level above background, which comprises:
- a) an effective amount of one or more diols having the following structure:
- wherein
- each R is independently selected from hydrogen;
- halogen;
- a group containing from one atom to twenty atoms, one of which is carbon, nitrogen, oxygen, or sulfur;
- hydroxyl;
- hydroxymethyl;
- —(CH2)nOH, —(CH2)nOR′;
- —(CH2)n—CH(OH)—CHOH;
- —(CH2)n—CH(OH)—CH(OH)R′;
- —(CH2)n—CH(OH)—(CH2)n—CH2(OH);
- —(CH2)n—CH(OH)—(CH2)n—CH(OH)R′;
- or —CH2OR′;
- wherein each n is independently an integer from 0-25;
- each R′ is independently selected from hydrogen or an acyl or amino acyl group containing from one atom to twenty atoms, at least one of which is carbon, nitrogen, oxygen, or sulfur;
- or pharmaceutically acceptable salts thereof;
- and
- b) a pharmaceutically suitable carrier.
Dependencies are inferred from the claim text.