Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds

An arylglycinamide derivative of formula I:

• or the pharmaceutically acceptable salts thereof, wherein
• Ar is unsubstituted or mono- to penta-substituted phenyl, or unsubstituted or mono- or di-substituted naphthyl, in which the substituents of the phenyl and naphthyl are independently selected from the group consisting of halogen, hydroxy, (C1-4)alkyl, O—(C1-4)alkyl, CF3, OCF3 and NR9R10, wherein R9 and R10 are independently selected from the group consisting of hydrogen, methyl and acetyl;
• or
• Ar is phenyl substituted by —O—CH2—O or —O—(CH2)2—O—;
• R1 and R2 together with the N to which they are bound form a ring of the formula
• wherein
• p is 2 or 3,
• X is CR7R8, wherein R7 and R8 have one of the following meanings:
• (a) R7 and R8 are each hydrogen when R3 is unsubstituted or substituted phenyl;
• (b) R7 is phenyl,
• phenyl substituted by 1 to 3 substituents, wherein the substituents are independently selected from the group consisting of halogen, (C1-4)alkyl, O—(C1-4)alkyl, CF3 and OCF3,
• piperidinyl,
• 1-methylpiperidinyl,
• when R8 is hydrogen, —CONH2, —NHC(O)CH3, —N(CH3)C(O)CH3, CN, —C(O)NH(C1-3)alkyl, or —C(O)N((C1-3)alkyl)2;
• or
• (c) R7 and R8 together form the group
• R3 is hydrogen, (C1-4)alkyl, unsubstituted phenyl or mono- to tri-substituted phenyl, wherein the substituents are independently selected from the group consisting of halogen, (C1-4)alkyl, O—(C1-4)alkyl, CF3, OCF3 and NR9R10, wherein R9 and R10 are independently selected from the group consisting of hydrogen, methyl and acetyl;
• R4 is phenyl (C1-4)alkyl or naphthyl (C1-4)alkyl, wherein phenyl is optionally substituted by 1 to 3 substituents, independently selected from the group consisting of halogen, (C1-4)alkyl, O—(C1-4)alkyl, CF3, OCF3 and NR9R10, wherein R9 and R10 are independently selected from the group consisting of hydrogen, methyl and acetyl;
• and
• R5 is hydrogen, (C1-4)alkyl, (C3-6)cycloalkyl, CH2COOH, —CH2C(O)NH2, hydroxy or phenyl (C1-4)alkyl.