Carbapenem antibacterial compounds, compositions containing such compounds and method of treatment

A compound represented by formula I:

• including pharmaceutically acceptable salts thereof, wherein:
• R1 represents H or methyl;
• CO2M represents a carboxylic acid, or carboxylate anion, provided that when CO2M represents a carboxylate anion it is balanced by Q;
• P represents hydrogen, hydroxyl or F;
• each R independently represents Rb,
• C2-6 alkenyl, or a group L—Q—Rq with the proviso that only one R group of the type L—Q—Rq can be present;
• L is C1-4 straight or branched alkylene, uninterrupted, or interrupted by 1-2 of O, S, NRa, C(O), CO2 and C(O)NRa;
• Q represents:
• Y− is a charge balancing group;
• n is a value from 1 to 2 selected to maintain overall charge neutrality;
• Ra is H or C1-6 alkyl;
• Rq is C1-6 alkyl, straight or branched, uninterrupted or interrupted by 1-2 of O, S, NRa, C(O), C(O)O, C(O)NRa, —CH═CH—, —Het(Rb)3—, —C(O)Het(Rb)3—,—C(O)NRaHet(Rb)3—,
• said Rq being unsubstituted or substituted with 1-3 Rc groups;
• Het is a heteroaryl group;
• each Rb is independently selected from H, halo, ORa, OC(O)Ra, C(O)Ra, CN, C(O)NRaRd, NO2, NRaRd, SO2NRaRd and C1-4 alkyl unsubstituted or substituted with 1-3 groups selected from Re;
• each Rc is independently selected from halo, ORf, OC(O)Rf, SRf, S(O)Rf, SO2Rf, CN, C(O)Rf, CO2Rf, NRfRg, N+RaRfRgZ−, C(O)NRaRf, −Het(Rb)3, C(═N+RaRf)RaZ−, C(═N+RaRf)NRaRfZ−, NRaC(═N+RaRf)RaZ−, NRaC(═N+RaRf)NRaRfZ−, heteroarylium(Rb)3Z−, SO2NRaRf, OC(O)NRaRf, NRaC(O)Rf, NRaC(O)NRaRf, and
• or in the alternative, when 2 or more Rc groups are present, 2 Rc groups may be taken together with any intervening atoms to form a 3-6 membered carbocyclic ring, optionally interrupted with 1-3 of O, S, NRg, and C(O), said ring being unsubstituted or substituted with 1-3 Re groups;
• Rd is H or C1-4 alkyl, or
• each Re is independently selected from halo, ORa, NRaRd and CONRaRd;
• Rf is H;
• C1-6 straight or branched chain alkyl, unsubstituted or substituted with 1-3 Re groups;
• —Het(Rb)3;
• C3-6 cycloallkyl, unsubstituted or substituted with 1-3 Re groups, and
• Rg is H, C1-6 alkyl, unsubstituted or substituted with 1-3 Re groups;
• C3-6 cycloalkyl, unsubstituted or substituted with 1-3 Re groups;
• C(═N+RaRf)RaZ− or C(═N+RaRf)NRaRfZ−, and
• Z is a charge balancing group selected from Y−.