Material for passage through the blood-brain barrier
OwnerAlbert T. Naitoinventor
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OwnerAlbert T. Naitoinventor
Estimating the term…
A material which has the ability to effect it's passage, at least in part, and the ability to transport other materials through the blood-brain barrier which includes any one or more pure sugars or pure amino sugars from the group consisting of meso ethritol, zylitol, D(+) galactose, D(+) lactose, D(+) xylose, dulcitol, myo-insoitol, L(−) fructose, D(−) mannitol, sorbitol, D(+) glucose, D(+) arabinose, D(−) arabinose, celloboise, D(+) maltose, D(+) raffinose, L(+)rhamnose, D(+) melibiose, D(−) ribose, adonitol, D(+) arabitol, L(−) arabitol, D(+) fucose, L(−) fucose, D(−) lyxose, L(+) lyxose, L(−) lyxose, D(+) glucosamine, D mannosamine, and D galactosamine; and any one or more amino acids from the group consisting of arginine, asparagine, aspartic acid, cysteine, glutamic acid, glycine, histidine, leucine, methionine, phenylalanine, proline, serine, threonine, glutamine, lysine, tryptophan, tyrosine, valine, and taurine. For use in the research or treatment of a subject that material is combined with one or more of the substances beta carotene, xanthophyll, lecithin, calcium, somatostatin, vasopressin, endorphin, enkephalin, acetyl-L-carnitine, GABA, dynorphin, L-tryptophan, choline, thiamine, pyridoxine, niacin, L-arginine, hydroxyproline, NGF, methionine, cystine, potassium, phosphorus, chlorine, sodium, vitamins A, B, C, D and E, and selenium.
A method for passing and transporting substances through the blood-brain barrier, said method comprising the oral administration to a human subject of a saccharide component sufficient to open the blood-brain barrier of the subject and an amino acid material to be thereafter transported across the blood-brain barrier and received in the brain of the subject, wherein the amino acid material comprises at least one of the amino acids selected from the group consisting of glutamine, lysine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glycine, histidine, leucine, methionine, phenylalanine, proline, serine, threonine, tyrosine, valine, and taurine.
A method for eliciting a therapeutic effect of a therapeutic chemical substance other than a sugar or an amino acid, comprising administering the substance to a patient in need thereof, orally co-administering a sugar and an amino acid in an amount sufficient to elicit the therapeutic effect of the substance, and permitting the substance to exert its therapeutic effect.
Dependencies are inferred from the claim text.