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AssigneesUniversity of Kentucky Research Foundation, ZymoGenetics, Inc.
InventorsPeter R. Oeltgen, Mark S. Kindy, Paul D. Bishop
Estimating the term…
A method for treating ischemia by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, delntorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration of about 0.5-20 mg/kg body weight, or alternatively a lower concentration of about 1-1000 μg/kg body weight of the mammal in a physiologically acceptable formulation is administered up to four hours after an ischemic episode. Deltorphins may also be administered prior to or concurrently with onset of ischemia. Cerebral or spinal cord ischemia or ischemic heart disease may be treated using the method of the invention.
A method of treating ischemia in a mammal experiencing ischemia comprising administering a deltorphin selected from the group consisting of deltorphin I represented by SEQ ID NO:1, deltorphin II represented by SEQ ID NO:2 and combinations thereof to the mammal in a parmaceutically acceptable formulation.
A method for treating cerebral ischemia in a mammal experiencing ischemia comprising administering a pharmaceutically effective concentration of a deltorphin selected from the group consisting of deltorphin I represented by SEQ ID NO:1, deltorohin II represented by SEQ ID NO:2 and combinations thereof.
A method for reducing effects of an ischemic episode in a mammal experiencing ischemia comprising administering a pharmaceutically effective concentration of a deltorphin selected from the group consisting of deltorphin I represented by SEQ ID NO:1, deltorphin II represented by SEQ ID NO:2 and combinations thereof.
A method of inhibiting ischemia in a mammal at risk for ischemia comprising administering a deltorphin selected from the group consisting of deltorphin I represented by SEQ ID NO:1, deltorphin II represented by SEQ ID NO:2 and combinations thereof to the mammal in a pharmaceutically acceptable formulation.
A method for inhibiting ischemia in a mammal at risk for ischemia comprising administering a pharmaceutically effective concentration of a deltorphin selected from the group consisting of deltorphin I represented by SEQ ID NO:1, deltorphin II represented by SEQ ID NO:2 and combinations thereof.
Dependencies are inferred from the claim text.